Marker enzymes of rat chemical hepatocarcinogenesis in human liver tumors

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Abstract

1st Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Budapest; Hungary Reduced glucose-6-phosphatase, increased GGT activity and reduction of cytochrome P-450 content are considered to be markers of chemical hepatocarcinogenesis in rats. The significance of these changes were studied in certain human liver lesions; adenoma, focal nodular hyperplasia and hepatocellular carcinoma all developed in noncirrhotic livers. Enzymes showed normal values in 4 out of 5 adenomas, in 2/13 FNH and in 4/18 HCC samples. The decreased cP-450 content in HCC proved to be the most consistent alteration (12/18). Only 3 HCC samples possessed changes off all enzymes. These data suggest that at least those enzymes which are used as markers in rat chemical hepatocarcinogenesis have little or no biological significance in human liver tumors, primarily due to the intertumoral heterogeneity of enzyme activity. Such heterogeneity was observed in the peritumoral "normal" liver tissue, too.

Original languageEnglish
Pages (from-to)56-58
Number of pages3
JournalPathology and Oncology Research
Volume2
Issue number1-2
DOIs
Publication statusPublished - Mar 1996

Fingerprint

Liver
Enzymes
Adenoma
Neoplasms
Focal Nodular Hyperplasia
Glucose-6-Phosphatase
Hungary
Cytochrome P-450 Enzyme System
Hepatocellular Carcinoma
Reference Values
Medicine
Pathology
Research

Keywords

  • cytochrome P-450
  • G-6-Pase
  • GGT
  • liver tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

Cite this

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abstract = "1st Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Budapest; Hungary Reduced glucose-6-phosphatase, increased GGT activity and reduction of cytochrome P-450 content are considered to be markers of chemical hepatocarcinogenesis in rats. The significance of these changes were studied in certain human liver lesions; adenoma, focal nodular hyperplasia and hepatocellular carcinoma all developed in noncirrhotic livers. Enzymes showed normal values in 4 out of 5 adenomas, in 2/13 FNH and in 4/18 HCC samples. The decreased cP-450 content in HCC proved to be the most consistent alteration (12/18). Only 3 HCC samples possessed changes off all enzymes. These data suggest that at least those enzymes which are used as markers in rat chemical hepatocarcinogenesis have little or no biological significance in human liver tumors, primarily due to the intertumoral heterogeneity of enzyme activity. Such heterogeneity was observed in the peritumoral {"}normal{"} liver tissue, too.",
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T1 - Marker enzymes of rat chemical hepatocarcinogenesis in human liver tumors

AU - Kovalszky, I.

AU - Schaff, Z.

AU - Lapis, K.

AU - Jeney, A.

PY - 1996/3

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N2 - 1st Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Budapest; Hungary Reduced glucose-6-phosphatase, increased GGT activity and reduction of cytochrome P-450 content are considered to be markers of chemical hepatocarcinogenesis in rats. The significance of these changes were studied in certain human liver lesions; adenoma, focal nodular hyperplasia and hepatocellular carcinoma all developed in noncirrhotic livers. Enzymes showed normal values in 4 out of 5 adenomas, in 2/13 FNH and in 4/18 HCC samples. The decreased cP-450 content in HCC proved to be the most consistent alteration (12/18). Only 3 HCC samples possessed changes off all enzymes. These data suggest that at least those enzymes which are used as markers in rat chemical hepatocarcinogenesis have little or no biological significance in human liver tumors, primarily due to the intertumoral heterogeneity of enzyme activity. Such heterogeneity was observed in the peritumoral "normal" liver tissue, too.

AB - 1st Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Budapest; Hungary Reduced glucose-6-phosphatase, increased GGT activity and reduction of cytochrome P-450 content are considered to be markers of chemical hepatocarcinogenesis in rats. The significance of these changes were studied in certain human liver lesions; adenoma, focal nodular hyperplasia and hepatocellular carcinoma all developed in noncirrhotic livers. Enzymes showed normal values in 4 out of 5 adenomas, in 2/13 FNH and in 4/18 HCC samples. The decreased cP-450 content in HCC proved to be the most consistent alteration (12/18). Only 3 HCC samples possessed changes off all enzymes. These data suggest that at least those enzymes which are used as markers in rat chemical hepatocarcinogenesis have little or no biological significance in human liver tumors, primarily due to the intertumoral heterogeneity of enzyme activity. Such heterogeneity was observed in the peritumoral "normal" liver tissue, too.

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