Marked differences of haplotype tagging SNP distribution, linkage, and haplotype profile of IL23 receptor gene in Roma and Hungarian population samples

L. Magyari, Dalma Varszegi, Patricia Sarlos, L. Járomi, Bela I. Melegh, Balazs Duga, P. Kisfali, Erzsebet Kovesdi, Petra Matyas, Andras Szabo, Renata Szalai, B. Melegh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Polymorphisms of the interleukin-23 receptor (IL23R) gene have been found to play an important role in the development of several autoimmune diseases. We examined five susceptible (rs10889677, rs1004819, rs2201841, rs11805303, rs11209032), one protective (rs7517847) and two neutral variants (rs7530511, rs1884444) of the IL23R gene in pooled DNA of healthy Roma (Gipsy) and Hungarian population samples. Our aim was to determine the genetic variability of the major haplotype tagging polymorphisms, and the haplotype profile of IL23R between the two groups. We analyzed 273 healthy Roma and 253 Hungarian DNA samples using PCR/RFLP assay. Comparing the five susceptible conferring alleles, there were significant increase (p

Original languageEnglish
Pages (from-to)148-152
Number of pages5
JournalCytokine
Volume65
Issue number2
DOIs
Publication statusPublished - 2014

Fingerprint

Interleukin Receptors
Interleukin-23
Haplotypes
Single Nucleotide Polymorphism
Genes
Polymorphism
Population
DNA
Restriction Fragment Length Polymorphisms
Autoimmune Diseases
Assays
Alleles
Polymerase Chain Reaction

Keywords

  • IL23R
  • Immune diseases
  • Roma
  • Susceptibility

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Hematology
  • Biochemistry
  • Molecular Biology

Cite this

Marked differences of haplotype tagging SNP distribution, linkage, and haplotype profile of IL23 receptor gene in Roma and Hungarian population samples. / Magyari, L.; Varszegi, Dalma; Sarlos, Patricia; Járomi, L.; Melegh, Bela I.; Duga, Balazs; Kisfali, P.; Kovesdi, Erzsebet; Matyas, Petra; Szabo, Andras; Szalai, Renata; Melegh, B.

In: Cytokine, Vol. 65, No. 2, 2014, p. 148-152.

Research output: Contribution to journalArticle

Magyari, L. ; Varszegi, Dalma ; Sarlos, Patricia ; Járomi, L. ; Melegh, Bela I. ; Duga, Balazs ; Kisfali, P. ; Kovesdi, Erzsebet ; Matyas, Petra ; Szabo, Andras ; Szalai, Renata ; Melegh, B. / Marked differences of haplotype tagging SNP distribution, linkage, and haplotype profile of IL23 receptor gene in Roma and Hungarian population samples. In: Cytokine. 2014 ; Vol. 65, No. 2. pp. 148-152.
@article{e12058179d6a4284937836fcfd7694e5,
title = "Marked differences of haplotype tagging SNP distribution, linkage, and haplotype profile of IL23 receptor gene in Roma and Hungarian population samples",
abstract = "Polymorphisms of the interleukin-23 receptor (IL23R) gene have been found to play an important role in the development of several autoimmune diseases. We examined five susceptible (rs10889677, rs1004819, rs2201841, rs11805303, rs11209032), one protective (rs7517847) and two neutral variants (rs7530511, rs1884444) of the IL23R gene in pooled DNA of healthy Roma (Gipsy) and Hungarian population samples. Our aim was to determine the genetic variability of the major haplotype tagging polymorphisms, and the haplotype profile of IL23R between the two groups. We analyzed 273 healthy Roma and 253 Hungarian DNA samples using PCR/RFLP assay. Comparing the five susceptible conferring alleles, there were significant increase (p",
keywords = "IL23R, Immune diseases, Roma, Susceptibility",
author = "L. Magyari and Dalma Varszegi and Patricia Sarlos and L. J{\'a}romi and Melegh, {Bela I.} and Balazs Duga and P. Kisfali and Erzsebet Kovesdi and Petra Matyas and Andras Szabo and Renata Szalai and B. Melegh",
year = "2014",
doi = "10.1016/j.cyto.2013.11.011",
language = "English",
volume = "65",
pages = "148--152",
journal = "Cytokine",
issn = "1043-4666",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Marked differences of haplotype tagging SNP distribution, linkage, and haplotype profile of IL23 receptor gene in Roma and Hungarian population samples

AU - Magyari, L.

AU - Varszegi, Dalma

AU - Sarlos, Patricia

AU - Járomi, L.

AU - Melegh, Bela I.

AU - Duga, Balazs

AU - Kisfali, P.

AU - Kovesdi, Erzsebet

AU - Matyas, Petra

AU - Szabo, Andras

AU - Szalai, Renata

AU - Melegh, B.

PY - 2014

Y1 - 2014

N2 - Polymorphisms of the interleukin-23 receptor (IL23R) gene have been found to play an important role in the development of several autoimmune diseases. We examined five susceptible (rs10889677, rs1004819, rs2201841, rs11805303, rs11209032), one protective (rs7517847) and two neutral variants (rs7530511, rs1884444) of the IL23R gene in pooled DNA of healthy Roma (Gipsy) and Hungarian population samples. Our aim was to determine the genetic variability of the major haplotype tagging polymorphisms, and the haplotype profile of IL23R between the two groups. We analyzed 273 healthy Roma and 253 Hungarian DNA samples using PCR/RFLP assay. Comparing the five susceptible conferring alleles, there were significant increase (p

AB - Polymorphisms of the interleukin-23 receptor (IL23R) gene have been found to play an important role in the development of several autoimmune diseases. We examined five susceptible (rs10889677, rs1004819, rs2201841, rs11805303, rs11209032), one protective (rs7517847) and two neutral variants (rs7530511, rs1884444) of the IL23R gene in pooled DNA of healthy Roma (Gipsy) and Hungarian population samples. Our aim was to determine the genetic variability of the major haplotype tagging polymorphisms, and the haplotype profile of IL23R between the two groups. We analyzed 273 healthy Roma and 253 Hungarian DNA samples using PCR/RFLP assay. Comparing the five susceptible conferring alleles, there were significant increase (p

KW - IL23R

KW - Immune diseases

KW - Roma

KW - Susceptibility

UR - http://www.scopus.com/inward/record.url?scp=84892482189&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892482189&partnerID=8YFLogxK

U2 - 10.1016/j.cyto.2013.11.011

DO - 10.1016/j.cyto.2013.11.011

M3 - Article

VL - 65

SP - 148

EP - 152

JO - Cytokine

JF - Cytokine

SN - 1043-4666

IS - 2

ER -