Mapping the calcitonin receptor in human brain stem

Rebekah L. Bower, Sajedeh Eftekhari, Henry J. Waldvogel, Richard L M Faull, J. Tajti, Lars Edvinsson, Debbie L. Hay, Christopher S. Walker

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The calcitonin receptor (CTR) is relevant to three hormonal systems: amylin, calcitonin, and calcitonin gene-related peptide (CGRP). Receptors for amylin and calcitonin are targets for treating obesity, diabetes, and bone disorders. CGRP receptors represent a target for pain and migraine. Amylin receptors (AMY) are a heterodimer formed by the coexpression of CTR with receptor activity-modifying proteins (RAMPs). CTR with RAMP1 responds potently to both amylin and CGRP. The brain stem is a major site of action for circulating amylin and is a rich site of CGRP binding. This study aimed to enhance our understanding of these hormone systems by mapping CTR expression in the human brain stem, specifically the medulla oblongata. Widespread CTR-like immunoreactivity was observed throughout the medulla. Dense CTR staining was noted in several discrete nuclei, including the nucleus of the solitary tract, the hypoglossal nucleus, the cuneate nucleus, spinal trigeminal nucleus, the gracile nucleus, and the inferior olivary nucleus. CTR staining was also observed in the area postrema, the lateral reticular nucleus, and the pyramidal tract. The extensive expression of CTR in the medulla suggests that CTR may be involved in a wider range of functions than currently appreciated.

Original languageEnglish
Pages (from-to)R788-R793
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume310
Issue number9
DOIs
Publication statusPublished - May 1 2016

Keywords

  • Amylin
  • Brain stem
  • Calcitonin gene-related peptide
  • Migraine
  • Obesity

ASJC Scopus subject areas

  • Physiology
  • Medicine(all)
  • Physiology (medical)

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  • Cite this

    Bower, R. L., Eftekhari, S., Waldvogel, H. J., Faull, R. L. M., Tajti, J., Edvinsson, L., Hay, D. L., & Walker, C. S. (2016). Mapping the calcitonin receptor in human brain stem. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 310(9), R788-R793. https://doi.org/10.1152/ajpregu.00539.2015