Mapping of quantitative trait loci for ethanol preference in quasi- congenic strains

Csaba Vadasz, Mariko Saito, Andrea Balla, Istvan Kiraly, Csaba Vadasz, Beatrix Gyetvai, E. Mikics, David Pierson, Donna Brown, James C. Nelson

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Ethanol preference, a component of alcoholism, has been known for four decades to differ greatly between C57BL/6 and BALB/c inbred mouse strains. For mapping quantitative trait loci (QTLs) that affect ethanol preference, we used a set of B6.C Recombinant QTL Introgression (RQI) strains, which carry about 5% of the donor BALB/cJ (C) genome on a C57BL/6ByJ (B6) background. After characterizing males of the progenitor and RQI strains for variations in ethanol preference, we scanned their genome for polymorphisms at 244 dinucleotide-repeat marker loci known to differ between B6 and C. Because of the introgression of BALB/c-type QTLs onto the B6 background, some strains showed ethanol preference significantly lower or higher than that of the background strain, suggesting that genetic interaction between ethanol preference QTLs and the background can be operative. The genomic region showing the strongest influence on ethanol preference was on mouse chromosome 15, and corresponds to human chr.12 q11-q13. (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)161-171
Number of pages11
JournalAlcohol
Volume20
Issue number2
DOIs
Publication statusPublished - Feb 2000

Fingerprint

Quantitative Trait Loci
Ethanol
Genes
Genome
Dinucleotide Repeats
Chromosomes, Human, Pair 15
Inbred Strains Mice
Chromosomes
Polymorphism
alcoholism
Alcoholism
interaction

Keywords

  • Alcohol preference
  • Animal model
  • Mouse
  • QTL mapping
  • Recombinant QTL introgression

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Behavioral Neuroscience
  • Neuroscience(all)
  • Toxicology
  • Health(social science)

Cite this

Vadasz, C., Saito, M., Balla, A., Kiraly, I., Vadasz, C., Gyetvai, B., ... Nelson, J. C. (2000). Mapping of quantitative trait loci for ethanol preference in quasi- congenic strains. Alcohol, 20(2), 161-171. https://doi.org/10.1016/S0741-8329(99)00068-3

Mapping of quantitative trait loci for ethanol preference in quasi- congenic strains. / Vadasz, Csaba; Saito, Mariko; Balla, Andrea; Kiraly, Istvan; Vadasz, Csaba; Gyetvai, Beatrix; Mikics, E.; Pierson, David; Brown, Donna; Nelson, James C.

In: Alcohol, Vol. 20, No. 2, 02.2000, p. 161-171.

Research output: Contribution to journalArticle

Vadasz, C, Saito, M, Balla, A, Kiraly, I, Vadasz, C, Gyetvai, B, Mikics, E, Pierson, D, Brown, D & Nelson, JC 2000, 'Mapping of quantitative trait loci for ethanol preference in quasi- congenic strains', Alcohol, vol. 20, no. 2, pp. 161-171. https://doi.org/10.1016/S0741-8329(99)00068-3
Vadasz C, Saito M, Balla A, Kiraly I, Vadasz C, Gyetvai B et al. Mapping of quantitative trait loci for ethanol preference in quasi- congenic strains. Alcohol. 2000 Feb;20(2):161-171. https://doi.org/10.1016/S0741-8329(99)00068-3
Vadasz, Csaba ; Saito, Mariko ; Balla, Andrea ; Kiraly, Istvan ; Vadasz, Csaba ; Gyetvai, Beatrix ; Mikics, E. ; Pierson, David ; Brown, Donna ; Nelson, James C. / Mapping of quantitative trait loci for ethanol preference in quasi- congenic strains. In: Alcohol. 2000 ; Vol. 20, No. 2. pp. 161-171.
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