Mapping of arthritogenic/autoimmune epitopes of cartilage aggrecans in proteoglycan-induced arthritis

T. T. Glant, C. Fülöp, G. Cs-Szabó, E. Búzás, D. Ragasa, K. Mikecz

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Immunization of BALB/c mice with chondroitin sulfate-depleted proteoglycan (aggrecan) of fetal human cartilage produces progressive polyarthritis and ankylosing spondylitis. The development of the disease in genetically susceptible BALB/c mice is dependent upon the expression of both cell-mediated and humoral immune responses against the host mouse cartilage proteoglycan (PG). Although cartilage PGs from various species have many biochemical and immunological similarities, only a select group of PGs from fetal and newborn human, fetal pig and canine articular cartilages, human osteophytes and human chondrosarcomas are able to induce arthritis in BALB/c mice. Arthritis develops only in mice that also develop autoantibodies to self-cartilage PGs, although autoantibodies occasionally are present in non-arthritic animals as well. The protease-sensitive auto/arthritogenic epitope(s) is located in, or close to, the chondroitin sulfate (CS) attachment region of the PG molecule. The primary structure of the core protein is responsible for the autoimmune/arthritogenic effect of this select group of PGs, whereas the core protein epitopes are masked by glycosaminoglycan (GAG)-side chains. The CS side chains seem to inhibit antigen recognition in all aggrecans with arthritogenic potential, whereas a similar effect with keratan sulfate (KS) appears only in PGs of aging cartilages.

Original languageEnglish
Pages (from-to)43-49
Number of pages7
JournalScandinavian Journal of Rheumatology
Volume24
Issue numberS101
DOIs
Publication statusPublished - 1995

Fingerprint

Aggrecans
Proteoglycans
Arthritis
Cartilage
Epitopes
Chondroitin Sulfates
Autoantibodies
Keratan Sulfate
Chondroitin Sulfate Proteoglycans
Osteophyte
Chondrosarcoma
Ankylosing Spondylitis
Articular Cartilage
Humoral Immunity
Glycosaminoglycans
Canidae
Amino Acid Sequence
Immunization
Peptide Hydrolases
Swine

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

Mapping of arthritogenic/autoimmune epitopes of cartilage aggrecans in proteoglycan-induced arthritis. / Glant, T. T.; Fülöp, C.; Cs-Szabó, G.; Búzás, E.; Ragasa, D.; Mikecz, K.

In: Scandinavian Journal of Rheumatology, Vol. 24, No. S101, 1995, p. 43-49.

Research output: Contribution to journalArticle

Glant, T. T. ; Fülöp, C. ; Cs-Szabó, G. ; Búzás, E. ; Ragasa, D. ; Mikecz, K. / Mapping of arthritogenic/autoimmune epitopes of cartilage aggrecans in proteoglycan-induced arthritis. In: Scandinavian Journal of Rheumatology. 1995 ; Vol. 24, No. S101. pp. 43-49.
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