MAO activity, serotonin metabolism and aggregation of platelets from migraine patients. A preliminary study.

K. Kovács, L. Tóthfalusi, F. Hermán, K. Magyar

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Platelets of migraine patients showed abnormal behavior such as hyperaggregability and reduced monoamine oxidase activity (MAO). We measured the MAO activity, serotonin (5-HT) content and release, adenosine diphosphate (ADP)-induced aggregation, and the prostacyclin (PGI2) antiaggregatory effect using the same sample of platelets from migraine patients to find out if these characteristics are intercorrelated. A significant correlation between MAO activity and sensitivity to PGI2 was found.

Original languageEnglish
Pages (from-to)691-695
Number of pages5
JournalPolish Journal of Pharmacology and Pharmacy
Volume40
Issue number6
Publication statusPublished - Nov 1988

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Monoamine Oxidase
Epoprostenol
Migraine Disorders
Platelet Aggregation
Serotonin
Blood Platelets
Adenosine Diphosphate

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

MAO activity, serotonin metabolism and aggregation of platelets from migraine patients. A preliminary study. / Kovács, K.; Tóthfalusi, L.; Hermán, F.; Magyar, K.

In: Polish Journal of Pharmacology and Pharmacy, Vol. 40, No. 6, 11.1988, p. 691-695.

Research output: Contribution to journalArticle

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