Mannose-Binding Lectin Levels and Carotid Intima-Media Thickness in Type 2 Diabetic Patients

Miklós Káplár, Shah Sweni, Julianna Kulcsár, Barbara Cogoi, Regina Esze, Sándor Somodi, M. Papp, L. Oláh, M. Magyar, Katalin Szabó, Katalin Réka Czuriga-Kovács, J. Hársfalvi, G. Paragh

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Introduction. Mannose-binding lectin (MBL) activates complement system and has been suggested to play a role in vascular complications in diabetics. Carotid intima-media thickness (cIMT) detects subclinical atherosclerosis. We evaluated the association of MBL and IMT in type 2 diabetic (T2DM) patients. Methods. Serum MBL levels and cIMT were measured in a total of 103 diabetics and in 98 age-matched healthy controls. Results. There was no significant difference in MBL level in T2DM versus controls. As expected, IMT was significantly higher in T2DM patients than in controls (P=0.001). In T2DM, the lowest cIMT was seen in patients with normal MBL level (500-1000) while cIMT continuously increased with both high MBL and absolute MBL deficiency states. This was especially significant in high MBL versus normal MBL T2DM patients (P=0.002). According to multiple regression analysis the main predictors of IMT in T2DM are age (P

Original languageEnglish
Article number8132925
JournalJournal of Diabetes Research
Volume2016
DOIs
Publication statusPublished - 2016

Fingerprint

Mannose-Binding Lectin
Carotid Intima-Media Thickness
Diabetic Angiopathies
Atherosclerosis
Regression Analysis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Mannose-Binding Lectin Levels and Carotid Intima-Media Thickness in Type 2 Diabetic Patients. / Káplár, Miklós; Sweni, Shah; Kulcsár, Julianna; Cogoi, Barbara; Esze, Regina; Somodi, Sándor; Papp, M.; Oláh, L.; Magyar, M.; Szabó, Katalin; Czuriga-Kovács, Katalin Réka; Hársfalvi, J.; Paragh, G.

In: Journal of Diabetes Research, Vol. 2016, 8132925, 2016.

Research output: Contribution to journalArticle

Káplár, Miklós ; Sweni, Shah ; Kulcsár, Julianna ; Cogoi, Barbara ; Esze, Regina ; Somodi, Sándor ; Papp, M. ; Oláh, L. ; Magyar, M. ; Szabó, Katalin ; Czuriga-Kovács, Katalin Réka ; Hársfalvi, J. ; Paragh, G. / Mannose-Binding Lectin Levels and Carotid Intima-Media Thickness in Type 2 Diabetic Patients. In: Journal of Diabetes Research. 2016 ; Vol. 2016.
@article{2ce766bca5384a0a84130fb0ae692a6c,
title = "Mannose-Binding Lectin Levels and Carotid Intima-Media Thickness in Type 2 Diabetic Patients",
abstract = "Introduction. Mannose-binding lectin (MBL) activates complement system and has been suggested to play a role in vascular complications in diabetics. Carotid intima-media thickness (cIMT) detects subclinical atherosclerosis. We evaluated the association of MBL and IMT in type 2 diabetic (T2DM) patients. Methods. Serum MBL levels and cIMT were measured in a total of 103 diabetics and in 98 age-matched healthy controls. Results. There was no significant difference in MBL level in T2DM versus controls. As expected, IMT was significantly higher in T2DM patients than in controls (P=0.001). In T2DM, the lowest cIMT was seen in patients with normal MBL level (500-1000) while cIMT continuously increased with both high MBL and absolute MBL deficiency states. This was especially significant in high MBL versus normal MBL T2DM patients (P=0.002). According to multiple regression analysis the main predictors of IMT in T2DM are age (P",
author = "Mikl{\'o}s K{\'a}pl{\'a}r and Shah Sweni and Julianna Kulcs{\'a}r and Barbara Cogoi and Regina Esze and S{\'a}ndor Somodi and M. Papp and L. Ol{\'a}h and M. Magyar and Katalin Szab{\'o} and Czuriga-Kov{\'a}cs, {Katalin R{\'e}ka} and J. H{\'a}rsfalvi and G. Paragh",
year = "2016",
doi = "10.1155/2016/8132925",
language = "English",
volume = "2016",
journal = "Journal of Diabetes Research",
issn = "2314-6745",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Mannose-Binding Lectin Levels and Carotid Intima-Media Thickness in Type 2 Diabetic Patients

AU - Káplár, Miklós

AU - Sweni, Shah

AU - Kulcsár, Julianna

AU - Cogoi, Barbara

AU - Esze, Regina

AU - Somodi, Sándor

AU - Papp, M.

AU - Oláh, L.

AU - Magyar, M.

AU - Szabó, Katalin

AU - Czuriga-Kovács, Katalin Réka

AU - Hársfalvi, J.

AU - Paragh, G.

PY - 2016

Y1 - 2016

N2 - Introduction. Mannose-binding lectin (MBL) activates complement system and has been suggested to play a role in vascular complications in diabetics. Carotid intima-media thickness (cIMT) detects subclinical atherosclerosis. We evaluated the association of MBL and IMT in type 2 diabetic (T2DM) patients. Methods. Serum MBL levels and cIMT were measured in a total of 103 diabetics and in 98 age-matched healthy controls. Results. There was no significant difference in MBL level in T2DM versus controls. As expected, IMT was significantly higher in T2DM patients than in controls (P=0.001). In T2DM, the lowest cIMT was seen in patients with normal MBL level (500-1000) while cIMT continuously increased with both high MBL and absolute MBL deficiency states. This was especially significant in high MBL versus normal MBL T2DM patients (P=0.002). According to multiple regression analysis the main predictors of IMT in T2DM are age (P

AB - Introduction. Mannose-binding lectin (MBL) activates complement system and has been suggested to play a role in vascular complications in diabetics. Carotid intima-media thickness (cIMT) detects subclinical atherosclerosis. We evaluated the association of MBL and IMT in type 2 diabetic (T2DM) patients. Methods. Serum MBL levels and cIMT were measured in a total of 103 diabetics and in 98 age-matched healthy controls. Results. There was no significant difference in MBL level in T2DM versus controls. As expected, IMT was significantly higher in T2DM patients than in controls (P=0.001). In T2DM, the lowest cIMT was seen in patients with normal MBL level (500-1000) while cIMT continuously increased with both high MBL and absolute MBL deficiency states. This was especially significant in high MBL versus normal MBL T2DM patients (P=0.002). According to multiple regression analysis the main predictors of IMT in T2DM are age (P

UR - http://www.scopus.com/inward/record.url?scp=84948417422&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84948417422&partnerID=8YFLogxK

U2 - 10.1155/2016/8132925

DO - 10.1155/2016/8132925

M3 - Article

C2 - 26640806

AN - SCOPUS:84948417422

VL - 2016

JO - Journal of Diabetes Research

JF - Journal of Diabetes Research

SN - 2314-6745

M1 - 8132925

ER -