Mannich base-connected syntheses mediated by ortho-quinone methides

Petra Barta, F. Fülöp, I. Szatmári

Research output: Contribution to journalReview article

10 Citations (Scopus)


This article provides an overview about specifically modified Mannich reactions where the process involves an ortho-quinone methide (o-QM) intermediate. The reactions are classified on the basis of the o-QM source followed by the reactant, e.g., the dienophile partner in cycloaddition reactions (C=C or C=N dienophiles) or by the formation of multicomponent Mannich adducts. Due to the important pharmacological activities of these reactive o-QM intermediates, special attention is paid to the biological activity of these compounds.

Original languageEnglish
Pages (from-to)560-575
Number of pages16
JournalBeilstein Journal of Organic Chemistry
Publication statusPublished - Mar 6 2018



  • Aminophenols
  • Dienophile
  • Mannich reaction
  • Ortho-quinone methide
  • [4 + 2] cycloaddition

ASJC Scopus subject areas

  • Organic Chemistry

Cite this