Manipulation of epitope function by modification of peptide structure: A minireview

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25 Citations (Scopus)


We have explored various approaches to modify the immunrecognition of linear peptides representing sequential or continuous topographic B-cell or T-cell epitopes. For these studies, epitopes from herpes simplex virus (HSV) glycoprotein D (gD) and from mucin 1 and mucin 2 glycoproteins or T-cell epitopes from 16 kDa and 38 kDa proteins of Mycobacterium tuberculosis were selected. To increase antigenicity and immunogenicity we have prepared cyclic and chimaeric peptide variants as well as epitope peptides with altered flanking regions and epitope-carrier conjugates containing multiple epitope copies.

Original languageEnglish
Pages (from-to)197-207
Number of pages11
Issue number3-4
Publication statusPublished - Jan 1 2001


  • Epitope flanking
  • Epitope peptide-conjugates
  • Epitope-chimaera
  • Epitopes of M. tuberculosis proteins
  • Mucin antibody epitopes
  • Protection against HSV infection
  • Synthetic peptide antigens

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology
  • Immunology and Microbiology(all)
  • Pharmacology

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