Manipulation of epitope function by modification of peptide structure: A minireview

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We have explored various approaches to modify the immunrecognition of linear peptides representing sequential or continuous topographic B-cell or T-cell epitopes. For these studies, epitopes from herpes simplex virus (HSV) glycoprotein D (gD) and from mucin 1 and mucin 2 glycoproteins or T-cell epitopes from 16 kDa and 38 kDa proteins of Mycobacterium tuberculosis were selected. To increase antigenicity and immunogenicity we have prepared cyclic and chimaeric peptide variants as well as epitope peptides with altered flanking regions and epitope-carrier conjugates containing multiple epitope copies.

Original languageEnglish
Pages (from-to)197-207
Number of pages11
JournalBiologicals
Volume29
Issue number3-4
DOIs
Publication statusPublished - 2001

Fingerprint

Epitopes
Peptides
T-Lymphocyte Epitopes
Glycoproteins
Mucin-2
T-cells
Mucin-1
Cyclic Peptides
Simplexvirus
Viruses
Mycobacterium tuberculosis
B-Lymphocytes
Cells
Proteins

Keywords

  • Epitope flanking
  • Epitope peptide-conjugates
  • Epitope-chimaera
  • Epitopes of M. tuberculosis proteins
  • Mucin antibody epitopes
  • Protection against HSV infection
  • Synthetic peptide antigens

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Infectious Diseases

Cite this

Manipulation of epitope function by modification of peptide structure : A minireview. / Hudecz, F.

In: Biologicals, Vol. 29, No. 3-4, 2001, p. 197-207.

Research output: Contribution to journalArticle

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