Management of paediatric ulcerative colitis, part 2

Acute severe colitis - An evidence-based consensus guideline from the european Crohn's and colitis organization and the european society of paediatric gastroenterology, hepatology and nutrition

Dan Turner, Frank M. Ruemmele, Esther Orlanski-Meyer, Anne M. Griffiths, Javier Martin De Carpi, Jiri Bronsky, G. Verès, Marina Aloi, Caterina Strisciuglio, Christian P. Braegger, Amit Assa, Claudio Romano, Seamus Hussey, Michael Stanton, Mikko Pakarinen, Lissy De Ridder, Konstantinos H. Katsanos, Nick Croft, Victor Manuel Navas-Lopez, David C. Wilson & 2 others Sally Lawrence, Richard K. Russell

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background and aim: Acute severe colitis (ASC) is one of the few emergencies in pediatric gastroenterology. Tight monitoring and timely medical and surgical interventions may improve outcomes and minimize morbidity and mortality. We aimed to standardize daily treatment of ASC in children through detailed recommendations and practice points which are based on a systematic review of the literature and consensus of experts. Methods: These guidelines are a joint effort of the European Crohn's and Colitis Organization (ECCO) and the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN). Fifteen predefined questions were addressed by working subgroups. An iterative consensus process, including 2 face-to-face meetings, was followed by voting of the national representatives of ECCO and all members of the Paediatric Inflammatory Bowel Disease (IBD) Porto group of ESPGHAN (43 voting experts). Results: A total of 24 recommendations and 43 practice points were endorsed with a consensus rate of at least 91% regarding diagnosis, monitoring, and management of ASC in children. A summary flowchart is presented based on daily scoring of the Paediatric Ulcerative Colitis Activity Index. Several topics have been altered since the previous 2011 guidelines and from those published in adults. Discussion: These guidelines standardize the management ofASC in children in an attempt to optimize outcomes of this intensive clinical scenario.

Original languageEnglish
Pages (from-to)292-310
Number of pages19
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume67
Issue number2
DOIs
Publication statusPublished - Jan 1 2018

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Gastroenterology
Colitis
Organizations
Guidelines
Pediatrics
Politics
Software Design
Inflammatory Bowel Diseases
Emergencies
Pediatric ulcerative colitis
Morbidity
Mortality

Keywords

  • acute severe colitis
  • anti-coagulants
  • anti-TNF
  • antibiotics
  • colectomy
  • mesalamine
  • Pediatric Ulcerative Colitis Activity Index
  • prediction
  • steroids
  • ulcerative colitis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

Cite this

Management of paediatric ulcerative colitis, part 2 : Acute severe colitis - An evidence-based consensus guideline from the european Crohn's and colitis organization and the european society of paediatric gastroenterology, hepatology and nutrition. / Turner, Dan; Ruemmele, Frank M.; Orlanski-Meyer, Esther; Griffiths, Anne M.; De Carpi, Javier Martin; Bronsky, Jiri; Verès, G.; Aloi, Marina; Strisciuglio, Caterina; Braegger, Christian P.; Assa, Amit; Romano, Claudio; Hussey, Seamus; Stanton, Michael; Pakarinen, Mikko; De Ridder, Lissy; Katsanos, Konstantinos H.; Croft, Nick; Navas-Lopez, Victor Manuel; Wilson, David C.; Lawrence, Sally; Russell, Richard K.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 67, No. 2, 01.01.2018, p. 292-310.

Research output: Contribution to journalArticle

Turner, D, Ruemmele, FM, Orlanski-Meyer, E, Griffiths, AM, De Carpi, JM, Bronsky, J, Verès, G, Aloi, M, Strisciuglio, C, Braegger, CP, Assa, A, Romano, C, Hussey, S, Stanton, M, Pakarinen, M, De Ridder, L, Katsanos, KH, Croft, N, Navas-Lopez, VM, Wilson, DC, Lawrence, S & Russell, RK 2018, 'Management of paediatric ulcerative colitis, part 2: Acute severe colitis - An evidence-based consensus guideline from the european Crohn's and colitis organization and the european society of paediatric gastroenterology, hepatology and nutrition', Journal of Pediatric Gastroenterology and Nutrition, vol. 67, no. 2, pp. 292-310. https://doi.org/10.1097/MPG.0000000000002036
Turner, Dan ; Ruemmele, Frank M. ; Orlanski-Meyer, Esther ; Griffiths, Anne M. ; De Carpi, Javier Martin ; Bronsky, Jiri ; Verès, G. ; Aloi, Marina ; Strisciuglio, Caterina ; Braegger, Christian P. ; Assa, Amit ; Romano, Claudio ; Hussey, Seamus ; Stanton, Michael ; Pakarinen, Mikko ; De Ridder, Lissy ; Katsanos, Konstantinos H. ; Croft, Nick ; Navas-Lopez, Victor Manuel ; Wilson, David C. ; Lawrence, Sally ; Russell, Richard K. / Management of paediatric ulcerative colitis, part 2 : Acute severe colitis - An evidence-based consensus guideline from the european Crohn's and colitis organization and the european society of paediatric gastroenterology, hepatology and nutrition. In: Journal of Pediatric Gastroenterology and Nutrition. 2018 ; Vol. 67, No. 2. pp. 292-310.
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AU - Turner, Dan

AU - Ruemmele, Frank M.

AU - Orlanski-Meyer, Esther

AU - Griffiths, Anne M.

AU - De Carpi, Javier Martin

AU - Bronsky, Jiri

AU - Verès, G.

AU - Aloi, Marina

AU - Strisciuglio, Caterina

AU - Braegger, Christian P.

AU - Assa, Amit

AU - Romano, Claudio

AU - Hussey, Seamus

AU - Stanton, Michael

AU - Pakarinen, Mikko

AU - De Ridder, Lissy

AU - Katsanos, Konstantinos H.

AU - Croft, Nick

AU - Navas-Lopez, Victor Manuel

AU - Wilson, David C.

AU - Lawrence, Sally

AU - Russell, Richard K.

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N2 - Background and aim: Acute severe colitis (ASC) is one of the few emergencies in pediatric gastroenterology. Tight monitoring and timely medical and surgical interventions may improve outcomes and minimize morbidity and mortality. We aimed to standardize daily treatment of ASC in children through detailed recommendations and practice points which are based on a systematic review of the literature and consensus of experts. Methods: These guidelines are a joint effort of the European Crohn's and Colitis Organization (ECCO) and the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN). Fifteen predefined questions were addressed by working subgroups. An iterative consensus process, including 2 face-to-face meetings, was followed by voting of the national representatives of ECCO and all members of the Paediatric Inflammatory Bowel Disease (IBD) Porto group of ESPGHAN (43 voting experts). Results: A total of 24 recommendations and 43 practice points were endorsed with a consensus rate of at least 91% regarding diagnosis, monitoring, and management of ASC in children. A summary flowchart is presented based on daily scoring of the Paediatric Ulcerative Colitis Activity Index. Several topics have been altered since the previous 2011 guidelines and from those published in adults. Discussion: These guidelines standardize the management ofASC in children in an attempt to optimize outcomes of this intensive clinical scenario.

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KW - steroids

KW - ulcerative colitis

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