Management of a twenty-first century brain bank

Experience in the BrainNet Europe consortium

Jeanne E. Bell, Irina Alafuzoff, Safa Al-Sarraj, Thomas Arzberger, Nenad Bogdanovic, Herbert Budka, David T. Dexter, Peter Falkai, Isidro Ferrer, Elena Gelpi, Steven M. Gentleman, Giorgio Giaccone, Inge Huitinga, James W. Ironside, Natasja Klioueva, Gabor G. Kovacs, David Meyronet, M. Palkóvits, Piero Parchi, Efstatios Patsouris & 9 others Richard Reynolds, Peter Riederer, Wolfgang Roggendorf, Danielle Seilhean, Andrea Schmitt, Peer Schmitz, Nathalie Streichenberger, Ameli Schwalber, Hans Kretzschmar

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Collections of human postmortem brains gathered in brain banks have underpinned many significant developments in the understanding of central nervous system (CNS) disorders and continue to support current research. Unfortunately, the worldwide decline in postmortem examinations has had an adverse effect on research tissue procurement, particularly from control cases (non-diseased brains). Recruitment to brain donor programmes partially addresses this problem and has been successful for dementing and neurodegenerative conditions. However, the collection of brains from control subjects, particularly from younger individuals, and from CNS disorders of sudden onset, remains a problem. Brain banks need to adopt additional strategies to circumvent such shortages. The establishment of brain bank networks allows data on, and access to, control cases and unusual CNS disorders to be shared, providing a larger resource for potential users. For the brain banks themselves, inclusion in a network fosters the sharing of protocols and development of best practice and quality control. One aspect of this collective experience concerns brain bank management, excellence in which is a prerequisite not only for gaining the trust of potential donors and of society in general, but also for ensuring equitable distribution to researchers of high quality tissue samples. This review addresses the legal, ethical and governance issues, tissue quality, and health and safety aspects of brain bank management and data management in a network, as well as the needs of users, brain bank staffing, donor programs, funding issues and public relations. Recent developments in research methodology present new opportunities for researchers who use brain tissue samples, but will require brain banks to adopt more complex protocols for tissue collection, preparation and storage, with inevitable cost implications for the future.

Original languageEnglish
Pages (from-to)497-507
Number of pages11
JournalActa Neuropathologica
Volume115
Issue number5
DOIs
Publication statusPublished - May 2008

Fingerprint

Brain
Central Nervous System Diseases
Research Personnel
Public Relations
Tissue and Organ Procurement
Practice Guidelines
Research
Ethics
Quality Control
Autopsy
Research Design
Databases
Safety
Costs and Cost Analysis
Health

Keywords

  • Brain banks
  • Networks
  • Postmortem examination
  • Tissue procurement
  • Tissue quality

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Bell, J. E., Alafuzoff, I., Al-Sarraj, S., Arzberger, T., Bogdanovic, N., Budka, H., ... Kretzschmar, H. (2008). Management of a twenty-first century brain bank: Experience in the BrainNet Europe consortium. Acta Neuropathologica, 115(5), 497-507. https://doi.org/10.1007/s00401-008-0360-8

Management of a twenty-first century brain bank : Experience in the BrainNet Europe consortium. / Bell, Jeanne E.; Alafuzoff, Irina; Al-Sarraj, Safa; Arzberger, Thomas; Bogdanovic, Nenad; Budka, Herbert; Dexter, David T.; Falkai, Peter; Ferrer, Isidro; Gelpi, Elena; Gentleman, Steven M.; Giaccone, Giorgio; Huitinga, Inge; Ironside, James W.; Klioueva, Natasja; Kovacs, Gabor G.; Meyronet, David; Palkóvits, M.; Parchi, Piero; Patsouris, Efstatios; Reynolds, Richard; Riederer, Peter; Roggendorf, Wolfgang; Seilhean, Danielle; Schmitt, Andrea; Schmitz, Peer; Streichenberger, Nathalie; Schwalber, Ameli; Kretzschmar, Hans.

In: Acta Neuropathologica, Vol. 115, No. 5, 05.2008, p. 497-507.

Research output: Contribution to journalArticle

Bell, JE, Alafuzoff, I, Al-Sarraj, S, Arzberger, T, Bogdanovic, N, Budka, H, Dexter, DT, Falkai, P, Ferrer, I, Gelpi, E, Gentleman, SM, Giaccone, G, Huitinga, I, Ironside, JW, Klioueva, N, Kovacs, GG, Meyronet, D, Palkóvits, M, Parchi, P, Patsouris, E, Reynolds, R, Riederer, P, Roggendorf, W, Seilhean, D, Schmitt, A, Schmitz, P, Streichenberger, N, Schwalber, A & Kretzschmar, H 2008, 'Management of a twenty-first century brain bank: Experience in the BrainNet Europe consortium', Acta Neuropathologica, vol. 115, no. 5, pp. 497-507. https://doi.org/10.1007/s00401-008-0360-8
Bell JE, Alafuzoff I, Al-Sarraj S, Arzberger T, Bogdanovic N, Budka H et al. Management of a twenty-first century brain bank: Experience in the BrainNet Europe consortium. Acta Neuropathologica. 2008 May;115(5):497-507. https://doi.org/10.1007/s00401-008-0360-8
Bell, Jeanne E. ; Alafuzoff, Irina ; Al-Sarraj, Safa ; Arzberger, Thomas ; Bogdanovic, Nenad ; Budka, Herbert ; Dexter, David T. ; Falkai, Peter ; Ferrer, Isidro ; Gelpi, Elena ; Gentleman, Steven M. ; Giaccone, Giorgio ; Huitinga, Inge ; Ironside, James W. ; Klioueva, Natasja ; Kovacs, Gabor G. ; Meyronet, David ; Palkóvits, M. ; Parchi, Piero ; Patsouris, Efstatios ; Reynolds, Richard ; Riederer, Peter ; Roggendorf, Wolfgang ; Seilhean, Danielle ; Schmitt, Andrea ; Schmitz, Peer ; Streichenberger, Nathalie ; Schwalber, Ameli ; Kretzschmar, Hans. / Management of a twenty-first century brain bank : Experience in the BrainNet Europe consortium. In: Acta Neuropathologica. 2008 ; Vol. 115, No. 5. pp. 497-507.
@article{2111fa32148f4a9b904bf44def66b907,
title = "Management of a twenty-first century brain bank: Experience in the BrainNet Europe consortium",
abstract = "Collections of human postmortem brains gathered in brain banks have underpinned many significant developments in the understanding of central nervous system (CNS) disorders and continue to support current research. Unfortunately, the worldwide decline in postmortem examinations has had an adverse effect on research tissue procurement, particularly from control cases (non-diseased brains). Recruitment to brain donor programmes partially addresses this problem and has been successful for dementing and neurodegenerative conditions. However, the collection of brains from control subjects, particularly from younger individuals, and from CNS disorders of sudden onset, remains a problem. Brain banks need to adopt additional strategies to circumvent such shortages. The establishment of brain bank networks allows data on, and access to, control cases and unusual CNS disorders to be shared, providing a larger resource for potential users. For the brain banks themselves, inclusion in a network fosters the sharing of protocols and development of best practice and quality control. One aspect of this collective experience concerns brain bank management, excellence in which is a prerequisite not only for gaining the trust of potential donors and of society in general, but also for ensuring equitable distribution to researchers of high quality tissue samples. This review addresses the legal, ethical and governance issues, tissue quality, and health and safety aspects of brain bank management and data management in a network, as well as the needs of users, brain bank staffing, donor programs, funding issues and public relations. Recent developments in research methodology present new opportunities for researchers who use brain tissue samples, but will require brain banks to adopt more complex protocols for tissue collection, preparation and storage, with inevitable cost implications for the future.",
keywords = "Brain banks, Networks, Postmortem examination, Tissue procurement, Tissue quality",
author = "Bell, {Jeanne E.} and Irina Alafuzoff and Safa Al-Sarraj and Thomas Arzberger and Nenad Bogdanovic and Herbert Budka and Dexter, {David T.} and Peter Falkai and Isidro Ferrer and Elena Gelpi and Gentleman, {Steven M.} and Giorgio Giaccone and Inge Huitinga and Ironside, {James W.} and Natasja Klioueva and Kovacs, {Gabor G.} and David Meyronet and M. Palk{\'o}vits and Piero Parchi and Efstatios Patsouris and Richard Reynolds and Peter Riederer and Wolfgang Roggendorf and Danielle Seilhean and Andrea Schmitt and Peer Schmitz and Nathalie Streichenberger and Ameli Schwalber and Hans Kretzschmar",
year = "2008",
month = "5",
doi = "10.1007/s00401-008-0360-8",
language = "English",
volume = "115",
pages = "497--507",
journal = "Acta Neuropathologica",
issn = "0001-6322",
publisher = "Springer Verlag",
number = "5",

}

TY - JOUR

T1 - Management of a twenty-first century brain bank

T2 - Experience in the BrainNet Europe consortium

AU - Bell, Jeanne E.

AU - Alafuzoff, Irina

AU - Al-Sarraj, Safa

AU - Arzberger, Thomas

AU - Bogdanovic, Nenad

AU - Budka, Herbert

AU - Dexter, David T.

AU - Falkai, Peter

AU - Ferrer, Isidro

AU - Gelpi, Elena

AU - Gentleman, Steven M.

AU - Giaccone, Giorgio

AU - Huitinga, Inge

AU - Ironside, James W.

AU - Klioueva, Natasja

AU - Kovacs, Gabor G.

AU - Meyronet, David

AU - Palkóvits, M.

AU - Parchi, Piero

AU - Patsouris, Efstatios

AU - Reynolds, Richard

AU - Riederer, Peter

AU - Roggendorf, Wolfgang

AU - Seilhean, Danielle

AU - Schmitt, Andrea

AU - Schmitz, Peer

AU - Streichenberger, Nathalie

AU - Schwalber, Ameli

AU - Kretzschmar, Hans

PY - 2008/5

Y1 - 2008/5

N2 - Collections of human postmortem brains gathered in brain banks have underpinned many significant developments in the understanding of central nervous system (CNS) disorders and continue to support current research. Unfortunately, the worldwide decline in postmortem examinations has had an adverse effect on research tissue procurement, particularly from control cases (non-diseased brains). Recruitment to brain donor programmes partially addresses this problem and has been successful for dementing and neurodegenerative conditions. However, the collection of brains from control subjects, particularly from younger individuals, and from CNS disorders of sudden onset, remains a problem. Brain banks need to adopt additional strategies to circumvent such shortages. The establishment of brain bank networks allows data on, and access to, control cases and unusual CNS disorders to be shared, providing a larger resource for potential users. For the brain banks themselves, inclusion in a network fosters the sharing of protocols and development of best practice and quality control. One aspect of this collective experience concerns brain bank management, excellence in which is a prerequisite not only for gaining the trust of potential donors and of society in general, but also for ensuring equitable distribution to researchers of high quality tissue samples. This review addresses the legal, ethical and governance issues, tissue quality, and health and safety aspects of brain bank management and data management in a network, as well as the needs of users, brain bank staffing, donor programs, funding issues and public relations. Recent developments in research methodology present new opportunities for researchers who use brain tissue samples, but will require brain banks to adopt more complex protocols for tissue collection, preparation and storage, with inevitable cost implications for the future.

AB - Collections of human postmortem brains gathered in brain banks have underpinned many significant developments in the understanding of central nervous system (CNS) disorders and continue to support current research. Unfortunately, the worldwide decline in postmortem examinations has had an adverse effect on research tissue procurement, particularly from control cases (non-diseased brains). Recruitment to brain donor programmes partially addresses this problem and has been successful for dementing and neurodegenerative conditions. However, the collection of brains from control subjects, particularly from younger individuals, and from CNS disorders of sudden onset, remains a problem. Brain banks need to adopt additional strategies to circumvent such shortages. The establishment of brain bank networks allows data on, and access to, control cases and unusual CNS disorders to be shared, providing a larger resource for potential users. For the brain banks themselves, inclusion in a network fosters the sharing of protocols and development of best practice and quality control. One aspect of this collective experience concerns brain bank management, excellence in which is a prerequisite not only for gaining the trust of potential donors and of society in general, but also for ensuring equitable distribution to researchers of high quality tissue samples. This review addresses the legal, ethical and governance issues, tissue quality, and health and safety aspects of brain bank management and data management in a network, as well as the needs of users, brain bank staffing, donor programs, funding issues and public relations. Recent developments in research methodology present new opportunities for researchers who use brain tissue samples, but will require brain banks to adopt more complex protocols for tissue collection, preparation and storage, with inevitable cost implications for the future.

KW - Brain banks

KW - Networks

KW - Postmortem examination

KW - Tissue procurement

KW - Tissue quality

UR - http://www.scopus.com/inward/record.url?scp=41949122431&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41949122431&partnerID=8YFLogxK

U2 - 10.1007/s00401-008-0360-8

DO - 10.1007/s00401-008-0360-8

M3 - Article

VL - 115

SP - 497

EP - 507

JO - Acta Neuropathologica

JF - Acta Neuropathologica

SN - 0001-6322

IS - 5

ER -