Malignant myoepithelioma of soft tissue

a case report with cytogenetic findings

Zsófia Balogh, Linda Deák, Z. Sápi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Soft tissue malignant myoepithelioma (STMM) is a particularly rare tumor displaying myoepithelial elements and lacking obvious ductal differentiation. From the one case report with cytogenetic data available in the literature, STMM seems to be a distinct entity with some resemblance to chordoma on the one hand and myoepithelioma on the other. The present case of STMM yielded novel data from high-resolution comparative genomic hybridization (HR-CGH) analysis. An 82-year-old female patient presented with a soft tissue tumor within the deep soft tissues in the right gluteal muscle measuring 16 × 13 × 11 cm. Histologically, the lesion was diagnosed as a myoepithelial carcinoma. Immunohistochemistry was focally positive for pancytokeratin, EMA, S-100 protein, and alpha smooth muscle actin. HR-CGH analysis revealed gains of 1p31∼p34, 1q21∼q23, 9q12∼q33, and 16q22 and losses of 1p11∼p22, 1q24∼q44, 3p, 10q11.1∼q22, 13q, 14q13∼q24, and 15q. Subsequent fluorescence in situ hybridization analysis confirmed deletion of 3p, gain of 16q, and monosomy of chromosomes 13 and 15. These results support the hypothesis that STMM is a distinct entity, not sharing the cytogenetic alterations of salivary gland myoepithelial carcinomas and ductal carcinomas of breast with myoepithelial differentiation.

Original languageEnglish
Pages (from-to)121-124
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume183
Issue number2
DOIs
Publication statusPublished - Jun 2008

Fingerprint

Myoepithelioma
Cytogenetics
Comparative Genomic Hybridization
Carcinoma, Ductal, Breast
Carcinoma
Chordoma
Monosomy
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 13
S100 Proteins
Salivary Glands
Fluorescence In Situ Hybridization
Smooth Muscle
Actins
Immunohistochemistry
Muscles

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Malignant myoepithelioma of soft tissue : a case report with cytogenetic findings. / Balogh, Zsófia; Deák, Linda; Sápi, Z.

In: Cancer Genetics and Cytogenetics, Vol. 183, No. 2, 06.2008, p. 121-124.

Research output: Contribution to journalArticle

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