Malignant lymphomas: Detection and quantification of MBR/JH2 t(14;18) BCL-2 gene rearrangement in follicular lymphoma using a combined real-time polymerase chain reaction assay

Erzsébet Csernák, Erika Tóth, Zsombor Melegh, Tamás Schneider, András Rosta, Zoltán Szentirmay

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We report our experience with a new real-time polymerase chain reaction (PCR) assay applicable for simultaneous quantification and characterization of MBR/JH translocation in follicular lymphomas. This technique, which combines amplification with the FRET probe with SYBR Green I melting curve analysis, allows efficient detection of tumor cells in bone marrow or peripheral blood and their comparison with the original neoplastic clone.

Original languageEnglish
Pages (from-to)858-859
Number of pages2
JournalHaematologica
Volume91
Issue number6
Publication statusPublished - Jun 1 2006

Keywords

  • Bcl-2 rearrangements
  • Melting curve analysis
  • Real-time PCR

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Malignant lymphomas: Detection and quantification of MBR/JH2 t(14;18) BCL-2 gene rearrangement in follicular lymphoma using a combined real-time polymerase chain reaction assay'. Together they form a unique fingerprint.

  • Cite this