Malignancies in systemic lupus erythematosus

Emese Kiss, Laszlo Kovacs, Peter Szodoray

Research output: Contribution to journalReview article

51 Citations (Scopus)

Abstract

Systemic lupus erythematosus (SLE) is a prototypical systemic autoimmune disease, characterized by a wide array of symptoms and organ involvements, leading to varying disease courses and outcome, and ranging from mild to severe types. In patients with SLE, the incidence and risk of malignancy development is increased, and mostly non-Hodgkin's lymphoma (NHL), cervical cancer, as well as bronchial carcinomas occur. Besides others, the common genetic predisposition, chronic antigen stimulus, disproportional immune responses, as well as the chronic administration of immunosuppressive medications can contribute to the development of malignancies in lupus. In this review we present the molecular pathology, as well as the epidemiological and clinical aspects of malignancies in patients with SLE.

Original languageEnglish
Pages (from-to)195-199
Number of pages5
JournalAutoimmunity Reviews
Volume9
Issue number4
DOIs
Publication statusPublished - Feb 1 2010

Keywords

  • EBV
  • Genetics
  • Lupus
  • Malignancy
  • Pathogenesis
  • Smoking

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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