Male reproductive tract abnormalities: More common after assisted reproduction?

Simone Funke, Edina Flach, István Kiss, J. Sándor, Gabriella Vida, József Bódis, Tibor Ertl

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background: In this era of increased use of assisted reproduction (AR) techniques, the prevalence rates of hypospadias, cryptorchidism, poor semen quality have been increasing in parallel with a rising incidence of testicular cancer. It is suggested that these problems result from the disruption of gonadal development during fetal life causing the testicular dysgenesis syndrome (TDS). Aim: The aim of our study was to evaluate the influence of conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), on the development of male genital tract abnormalities. Study design and subjects: We analyzed a cohort of 15,206 neonates born from January 1, 1999 through December 31, 2008 at the Department of Obstetrics and Gynecology, Medical School, University of Pécs, including 890 children (5.9%) born after IVF or ICSI. We examined the association between these AR methods and developmental abnormalities of the genital tract (hypospadias, cryptorchidism), after controlling for potential confounding factors, such as prematurity, low birthweight and twinning. Results: Preterm birth and low birthweight are risk factors for hypospadias and cryptorchidism (p2500. g) infants (OR: 3.966, 95%CI: 1.193-13.181, respectively). Similar but not nonsignificant trends were seen for cryptorchidism. Conclusion: IVF and ICSI, by increasing the risks of prematurity, low birthweight, and multiple gestation, are indirect risk factors for developing male genital malformations. In infants with normal birhtweight or from singleton pregnancies, ICSI is a specific risk factor for hypospadias.

Original languageEnglish
Pages (from-to)547-550
Number of pages4
JournalEarly Human Development
Volume86
Issue number9
DOIs
Publication statusPublished - Sep 2010

Fingerprint

Hypospadias
Cryptorchidism
Intracytoplasmic Sperm Injections
Reproduction
Fertilization in Vitro
Reproductive Techniques
Pregnancy
Hospital Obstetrics and Gynecology Department
Semen Analysis
Premature Birth
Testicular Neoplasms
Fetal Development
Medical Schools
Gynecology
Newborn Infant
Incidence

Keywords

  • Assisted reproduction
  • Male reproductive tract abnormalities
  • Testicular dysgenesis syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

Cite this

Male reproductive tract abnormalities : More common after assisted reproduction? / Funke, Simone; Flach, Edina; Kiss, István; Sándor, J.; Vida, Gabriella; Bódis, József; Ertl, Tibor.

In: Early Human Development, Vol. 86, No. 9, 09.2010, p. 547-550.

Research output: Contribution to journalArticle

Funke, Simone ; Flach, Edina ; Kiss, István ; Sándor, J. ; Vida, Gabriella ; Bódis, József ; Ertl, Tibor. / Male reproductive tract abnormalities : More common after assisted reproduction?. In: Early Human Development. 2010 ; Vol. 86, No. 9. pp. 547-550.
@article{2394812b704f46398093c893c199da94,
title = "Male reproductive tract abnormalities: More common after assisted reproduction?",
abstract = "Background: In this era of increased use of assisted reproduction (AR) techniques, the prevalence rates of hypospadias, cryptorchidism, poor semen quality have been increasing in parallel with a rising incidence of testicular cancer. It is suggested that these problems result from the disruption of gonadal development during fetal life causing the testicular dysgenesis syndrome (TDS). Aim: The aim of our study was to evaluate the influence of conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), on the development of male genital tract abnormalities. Study design and subjects: We analyzed a cohort of 15,206 neonates born from January 1, 1999 through December 31, 2008 at the Department of Obstetrics and Gynecology, Medical School, University of P{\'e}cs, including 890 children (5.9{\%}) born after IVF or ICSI. We examined the association between these AR methods and developmental abnormalities of the genital tract (hypospadias, cryptorchidism), after controlling for potential confounding factors, such as prematurity, low birthweight and twinning. Results: Preterm birth and low birthweight are risk factors for hypospadias and cryptorchidism (p2500. g) infants (OR: 3.966, 95{\%}CI: 1.193-13.181, respectively). Similar but not nonsignificant trends were seen for cryptorchidism. Conclusion: IVF and ICSI, by increasing the risks of prematurity, low birthweight, and multiple gestation, are indirect risk factors for developing male genital malformations. In infants with normal birhtweight or from singleton pregnancies, ICSI is a specific risk factor for hypospadias.",
keywords = "Assisted reproduction, Male reproductive tract abnormalities, Testicular dysgenesis syndrome",
author = "Simone Funke and Edina Flach and Istv{\'a}n Kiss and J. S{\'a}ndor and Gabriella Vida and J{\'o}zsef B{\'o}dis and Tibor Ertl",
year = "2010",
month = "9",
doi = "10.1016/j.earlhumdev.2010.06.015",
language = "English",
volume = "86",
pages = "547--550",
journal = "Early Human Development",
issn = "0378-3782",
publisher = "Elsevier Ireland Ltd",
number = "9",

}

TY - JOUR

T1 - Male reproductive tract abnormalities

T2 - More common after assisted reproduction?

AU - Funke, Simone

AU - Flach, Edina

AU - Kiss, István

AU - Sándor, J.

AU - Vida, Gabriella

AU - Bódis, József

AU - Ertl, Tibor

PY - 2010/9

Y1 - 2010/9

N2 - Background: In this era of increased use of assisted reproduction (AR) techniques, the prevalence rates of hypospadias, cryptorchidism, poor semen quality have been increasing in parallel with a rising incidence of testicular cancer. It is suggested that these problems result from the disruption of gonadal development during fetal life causing the testicular dysgenesis syndrome (TDS). Aim: The aim of our study was to evaluate the influence of conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), on the development of male genital tract abnormalities. Study design and subjects: We analyzed a cohort of 15,206 neonates born from January 1, 1999 through December 31, 2008 at the Department of Obstetrics and Gynecology, Medical School, University of Pécs, including 890 children (5.9%) born after IVF or ICSI. We examined the association between these AR methods and developmental abnormalities of the genital tract (hypospadias, cryptorchidism), after controlling for potential confounding factors, such as prematurity, low birthweight and twinning. Results: Preterm birth and low birthweight are risk factors for hypospadias and cryptorchidism (p2500. g) infants (OR: 3.966, 95%CI: 1.193-13.181, respectively). Similar but not nonsignificant trends were seen for cryptorchidism. Conclusion: IVF and ICSI, by increasing the risks of prematurity, low birthweight, and multiple gestation, are indirect risk factors for developing male genital malformations. In infants with normal birhtweight or from singleton pregnancies, ICSI is a specific risk factor for hypospadias.

AB - Background: In this era of increased use of assisted reproduction (AR) techniques, the prevalence rates of hypospadias, cryptorchidism, poor semen quality have been increasing in parallel with a rising incidence of testicular cancer. It is suggested that these problems result from the disruption of gonadal development during fetal life causing the testicular dysgenesis syndrome (TDS). Aim: The aim of our study was to evaluate the influence of conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), on the development of male genital tract abnormalities. Study design and subjects: We analyzed a cohort of 15,206 neonates born from January 1, 1999 through December 31, 2008 at the Department of Obstetrics and Gynecology, Medical School, University of Pécs, including 890 children (5.9%) born after IVF or ICSI. We examined the association between these AR methods and developmental abnormalities of the genital tract (hypospadias, cryptorchidism), after controlling for potential confounding factors, such as prematurity, low birthweight and twinning. Results: Preterm birth and low birthweight are risk factors for hypospadias and cryptorchidism (p2500. g) infants (OR: 3.966, 95%CI: 1.193-13.181, respectively). Similar but not nonsignificant trends were seen for cryptorchidism. Conclusion: IVF and ICSI, by increasing the risks of prematurity, low birthweight, and multiple gestation, are indirect risk factors for developing male genital malformations. In infants with normal birhtweight or from singleton pregnancies, ICSI is a specific risk factor for hypospadias.

KW - Assisted reproduction

KW - Male reproductive tract abnormalities

KW - Testicular dysgenesis syndrome

UR - http://www.scopus.com/inward/record.url?scp=77956340531&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956340531&partnerID=8YFLogxK

U2 - 10.1016/j.earlhumdev.2010.06.015

DO - 10.1016/j.earlhumdev.2010.06.015

M3 - Article

C2 - 20674196

AN - SCOPUS:77956340531

VL - 86

SP - 547

EP - 550

JO - Early Human Development

JF - Early Human Development

SN - 0378-3782

IS - 9

ER -