Malaria pigment crystals as magnetic micro-rotors: Key for high-sensitivity diagnosis

A. Butykai, A. Orbán, V. Kocsis, D. Szaller, S. Bordács, E. Tátrai-Szekeres, L. Kiss, A. Bóta, B. Vértessy, T. Zelles, I. Kézsmárki

Research output: Contribution to journalArticle

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Abstract

The need to develop new methods for the high-sensitivity diagnosis of malaria has initiated a global activity in medical and interdisciplinary sciences. Most of the diverse variety of emerging techniques are based on research-grade instruments, sophisticated reagent-based assays or rely on expertise. Here, we suggest an alternative optical methodology with an easy-to-use and cost-effective instrumentation based on unique properties of malaria pigment reported previously and determined quantitatively in the present study. Malaria pigment, also called hemozoin, is an insoluble microcrystalline form of heme. These crystallites show remarkable magnetic and optical anisotropy distinctly from any other components of blood. As a consequence, they can simultaneously act as magnetically driven micro-rotors and spinning polarizers in suspensions. These properties can gain importance not only in malaria diagnosis and therapies, where hemozoin is considered as drug target or immune modulator, but also in the magnetic manipulation of cells and tissues on the microscopic scale.

Original languageEnglish
Article number1431
JournalScientific Reports
Volume3
DOIs
Publication statusPublished - 2013

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Malaria
Anisotropy
Heme
Suspensions
Costs and Cost Analysis
hemozoin
Research
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • General

Cite this

Butykai, A., Orbán, A., Kocsis, V., Szaller, D., Bordács, S., Tátrai-Szekeres, E., ... Kézsmárki, I. (2013). Malaria pigment crystals as magnetic micro-rotors: Key for high-sensitivity diagnosis. Scientific Reports, 3, [1431]. https://doi.org/10.1038/srep01431

Malaria pigment crystals as magnetic micro-rotors : Key for high-sensitivity diagnosis. / Butykai, A.; Orbán, A.; Kocsis, V.; Szaller, D.; Bordács, S.; Tátrai-Szekeres, E.; Kiss, L.; Bóta, A.; Vértessy, B.; Zelles, T.; Kézsmárki, I.

In: Scientific Reports, Vol. 3, 1431, 2013.

Research output: Contribution to journalArticle

Butykai A, Orbán A, Kocsis V, Szaller D, Bordács S, Tátrai-Szekeres E et al. Malaria pigment crystals as magnetic micro-rotors: Key for high-sensitivity diagnosis. Scientific Reports. 2013;3. 1431. https://doi.org/10.1038/srep01431
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