Making the Case for a Candidate Vulnerability Gene in Schizophrenia

Convergent Evidence for Regulator of G-Protein Signaling 4 (RGS4)

Pat Levitt, Philip Ebert, K. Mirnics, Vishwajit L. Nimgaonkar, David A. Lewis

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Both genetic and environmental factors have been associated with an increased risk for schizophrenia. These factors are not mutually exclusive; a single gene can be a genetic factor (due to a mutation in the gene sequence) and a target of a physiological response to an environmental stimulus, both with the common endpoint of altered expression of the gene. Regulator of G-protein signaling 4 (RGS4) has been implicated as such a gene from three lines of evidence. First, a subset of genetic studies revealed an association between schizophrenia and non-functional polymorphisms in the RGS4 gene. Second, across the cortical mantle the expression of RGS4 mRNA is decreased in a diagnosis-specific manner in subjects with schizophrenia. Third, neurobiological studies demonstrate that RGS4 is highly responsive to environmental stimuli and capable of modulating the function of G-protein coupled neurotransmitter receptors implicated in schizophrenia. RGS4 is an example of a molecule that may underlie increased vulnerability through either genetic or non-genetic mechanisms, which we suggest may be typical of other genes in a complex, polygenic disorder such as schizophrenia.

Original languageEnglish
Pages (from-to)534-537
Number of pages4
JournalBiological Psychiatry
Volume60
Issue number6
DOIs
Publication statusPublished - Sep 15 2006

Fingerprint

GTP-Binding Protein Regulators
Schizophrenia
Genes
Neurotransmitter Receptor
Genetic Association Studies
G-Protein-Coupled Receptors
Gene Expression
Messenger RNA
Mutation

Keywords

  • gene-environment
  • neurodevelopment
  • RGS proteins
  • schizophrenia
  • Synaptic function

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Making the Case for a Candidate Vulnerability Gene in Schizophrenia : Convergent Evidence for Regulator of G-Protein Signaling 4 (RGS4). / Levitt, Pat; Ebert, Philip; Mirnics, K.; Nimgaonkar, Vishwajit L.; Lewis, David A.

In: Biological Psychiatry, Vol. 60, No. 6, 15.09.2006, p. 534-537.

Research output: Contribution to journalArticle

Levitt, Pat ; Ebert, Philip ; Mirnics, K. ; Nimgaonkar, Vishwajit L. ; Lewis, David A. / Making the Case for a Candidate Vulnerability Gene in Schizophrenia : Convergent Evidence for Regulator of G-Protein Signaling 4 (RGS4). In: Biological Psychiatry. 2006 ; Vol. 60, No. 6. pp. 534-537.
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