Major factors influencing in vitro drug release from suppositories

G. Regdon, Z. Muskö, G. Regdon, I. Erös

Research output: Contribution to journalArticle

4 Citations (Scopus)


The authors studied several important factors which influence in vitro drug release from suppositories. The biopharmaceutical aspect makes it essential to know these factors. The suppositories contained antirheumatic piroxicam, which was used as the model substance. Fourteen lipophilic and hydrophilic suppository bases with various hydroxyl numbers were tested experimentally, β-cyclodextrin was used to increase solubility, while tensides with different hydrophilic/lipophilic balance values served to increase moistening and pharmacon liberation. The best results were obtained with suppositories prepared with the Witepsol HI5 vehicle, when this base was used no problems of production technology were encountered, the physical parameters of the suppositories (solidity, disintegration time) were adequate and the in vitro pharmacon liberation was also optimal. Acceptor phases with different pH values were used during the membrane diffusion studies, and the best result was obtained with a pH of 7.5.

Original languageEnglish
Pages (from-to)191-196
Number of pages6
JournalS.T.P. Pharma Sciences
Issue number2
Publication statusPublished - Mar 1 1999


  • In vitro drug release
  • Optimal vehicle
  • Piroxicam
  • Rectal suppository
  • Rectal therapy

ASJC Scopus subject areas

  • Pharmaceutical Science

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