Major and trace elements in whole blood of phlebotomized patients with porphyria cutanea tarda

Mariann Dinya, E. Székely, K. Szentmihályi, Gy Tasnádi, A. Blázovics

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Porphyria cutanea tarda (PCT) is a disorder of hem biosynthesis resulting from a decreased activity of the uroporphyrinogen decarboxylase enzyme. Hem precursors are accumulated in the blood, liver and skin. Inherited and acquired factors also contribute to the pathogenesis of PCT. Hem precursors and porphyrins are excreted with urine and faeces. Whole blood of 8 PCT patients and 6 volunteers of Caucasian origin were analysed. In addition to routine laboratory measurements, 19 elements (Al, B, Ba, Ca, Cd, Co, Cu, Fe, K, Li, Mg, Mn, Mo, Na, Ni, P, S, V, Zn) were determined by means of inductively coupled plasma optical emission spectrometry (ICP-OES). Mg, P and S concentrations in whole blood were decreased significantly (p

Original languageEnglish
Pages (from-to)217-220
Number of pages4
JournalJournal of Trace Elements in Medicine and Biology
Volume19
Issue number2-3
DOIs
Publication statusPublished - Dec 2 2005

Fingerprint

Porphyria Cutanea Tarda
Trace Elements
Blood
Uroporphyrinogen Decarboxylase
Biosynthesis
Porphyrins
Inductively coupled plasma
Feces
Liver
Spectrometry
Volunteers
Spectrum Analysis
Skin
Urine
Enzymes

Keywords

  • ICP-OES
  • Major and trace elements
  • Porphyria cutanea tarda (PCT)

ASJC Scopus subject areas

  • Biochemistry
  • Public Health, Environmental and Occupational Health

Cite this

Major and trace elements in whole blood of phlebotomized patients with porphyria cutanea tarda. / Dinya, Mariann; Székely, E.; Szentmihályi, K.; Tasnádi, Gy; Blázovics, A.

In: Journal of Trace Elements in Medicine and Biology, Vol. 19, No. 2-3, 02.12.2005, p. 217-220.

Research output: Contribution to journalArticle

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