Maintenance of morphology and tumour marker production in human epidermoid lung carcinoma xenografts

M. Bak, J. Mattern, M. Volm

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The histopathology and the expression of various marker substances including cytokeratin, epithelial membrane antigen (EMA) and carcinoembryonic antigen (CEA) of ten human epidermoid lung carcinoma xenograft lines were compared with the corresponding donor patient tumours. It was found that the histological structure and the tumour markers were maintained by the xenografts. Neoplastic cells were more effectively detected using anti-keratin antibodies as compared to antibodies against EMA. CEA immunoreactivity was more common in well differentiated tumours. With the aid of electron microscopy, the known cellular heterogeneity of epidermoid lung carcinomas in man was also confirmed in these xenografts.

Original languageEnglish
Pages (from-to)319-326
Number of pages8
JournalIn Vivo
Volume1
Issue number5
Publication statusPublished - 1987

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Tumor Biomarkers
Heterografts
Squamous Cell Carcinoma
Mucin-1
Carcinoembryonic Antigen
Maintenance
Keratins
Lung
Tumors
Antibodies
Electron microscopy
Anti-Idiotypic Antibodies
Neoplasms
Electron Microscopy
Tissue Donors

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Maintenance of morphology and tumour marker production in human epidermoid lung carcinoma xenografts. / Bak, M.; Mattern, J.; Volm, M.

In: In Vivo, Vol. 1, No. 5, 1987, p. 319-326.

Research output: Contribution to journalArticle

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