Magnetite nanoparticles stabilized under physiological conditions for biomedical application

A. Hajdú, E. Tombácz, E. Illés, D. Bica, L. Vékás

Research output: Chapter in Book/Report/Conference proceedingConference contribution

45 Citations (Scopus)

Abstract

The biomedical application of water based magnetic fluids (MFs) is of great practical importance. Their colloidal stability under physiological conditions (blood pH ∼ 7.2-7.4 and salt concentration ∼0.15 M) and more in high magnetic field gradient is crucial. Magnetite or maghemite nanoparticles are used in general. In the present work, magnetite nanoparticles were stabilized with different compounds (citric acid (CA) and phosphate) and sodium oleate (NaO) as the most used surfactant in the stabilization of MFs. The adsorption and overcharging effect were quantified, and the enhancement in salt tolerance of stabilized systems was studied. Adsorption, electrophoretic mobility and dynamic light scattering (DLS) measurements were performed. The electrolyte tolerance was tested in coagulation kinetic measurements. Above the adsorption saturation, the nanoparticles are stabilized in a way of combined steric and electrostatic effects. The aim was to research these two important effects and demonstrate that none of them alone is enough. The phosphate was not able to stabilize the ferrofluid in spite of our expectation, but the other two additives proved to be effective stabilizing agents. The magnetite was well stabilized by the surface complexation of CA above pH ∼ 5, however, the salt tolerance of citrate stabilized MFs remained much below the concentration of physiological salt solution, and more the dissolution of magnetite nanocrystals was enhanced due to Fe-CA complexation in aqueous medium, which may cause problems in vivo. The oleate double layers were able to stabilize magnetite nanoparticles perfectly at pH ∼ 6 preventing particle aggregation effectively even in physiological salt solution.

Original languageEnglish
Title of host publicationProgress in Colloid and Polymer Science
Pages29-37
Number of pages9
Volume135
DOIs
Publication statusPublished - 2008

Publication series

NameProgress in Colloid and Polymer Science
Volume135
ISSN (Print)0340255X

Fingerprint

Magnetite Nanoparticles
Magnetite nanoparticles
Magnetic fluids
magnetite
Ferrosoferric Oxide
Citric Acid
Salts
citric acid
salts
Citric acid
Magnetite
nanoparticles
Complexation
Adsorption
adsorption
fluids
phosphates
Phosphates
Nanoparticles
Electrophoretic mobility

Keywords

  • Electrosteric stabilization
  • Magnetite
  • Surface complexation
  • Surfactant double layers
  • Water-based magnetic fluid

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry
  • Materials Chemistry
  • Polymers and Plastics

Cite this

Hajdú, A., Tombácz, E., Illés, E., Bica, D., & Vékás, L. (2008). Magnetite nanoparticles stabilized under physiological conditions for biomedical application. In Progress in Colloid and Polymer Science (Vol. 135, pp. 29-37). (Progress in Colloid and Polymer Science; Vol. 135). https://doi.org/10.1007/2882-2008-111

Magnetite nanoparticles stabilized under physiological conditions for biomedical application. / Hajdú, A.; Tombácz, E.; Illés, E.; Bica, D.; Vékás, L.

Progress in Colloid and Polymer Science. Vol. 135 2008. p. 29-37 (Progress in Colloid and Polymer Science; Vol. 135).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hajdú, A, Tombácz, E, Illés, E, Bica, D & Vékás, L 2008, Magnetite nanoparticles stabilized under physiological conditions for biomedical application. in Progress in Colloid and Polymer Science. vol. 135, Progress in Colloid and Polymer Science, vol. 135, pp. 29-37. https://doi.org/10.1007/2882-2008-111
Hajdú A, Tombácz E, Illés E, Bica D, Vékás L. Magnetite nanoparticles stabilized under physiological conditions for biomedical application. In Progress in Colloid and Polymer Science. Vol. 135. 2008. p. 29-37. (Progress in Colloid and Polymer Science). https://doi.org/10.1007/2882-2008-111
Hajdú, A. ; Tombácz, E. ; Illés, E. ; Bica, D. ; Vékás, L. / Magnetite nanoparticles stabilized under physiological conditions for biomedical application. Progress in Colloid and Polymer Science. Vol. 135 2008. pp. 29-37 (Progress in Colloid and Polymer Science).
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