Magnetic Resonance Imaging of Rat C6 Glioma Model Enhanced by Using Water-Soluble Gadolinium Fullerene

M. A. Shevtsov, B. P. Nikolaev, Ya Yu Marchenko, L. Y. Yakovleva, A. V. Dobrodumov, G. Török, E. Pitkin, V. T. Lebedev

Research output: Contribution to journalArticle

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Abstract

Water-soluble gadofullerene Gd@Ful with composition Gd3+@C82(OH)X 3- (x ~ 20) was synthesized for theranostic study. Nanosuspensions of Gd@Ful were used for magnetic relaxation measurements in vitro and for magnetic resonance imaging of a rat with intracranially implanted C6 glioma. Gd@Ful was shown to reduce proton relaxation times in vitro and provide dual contrast of T 1- and T 2-weighted images in a rat brain tumor model after paramagnetic intravenous delivery. Magnetic relaxation times of water protons under action of Gd@Ful were strongly shortened due to cluster formation and increase of motional correlation times of protons in the vicinity of the fullerene cage. The Gd@Ful administration promoted the improvement of glioma contrast enhancement at T 2-weighted images due to accumulation of paramagnetic substance at the tumor site. The contrast efficiency of Gd@Ful corresponds to the characteristics of negative contrast agent. The Gd@Ful nanosuspension is shown to be a contrast enhancer with high anti-tumor therapeutic potency. The retention of the Gd@Ful in the tumor resulted in a 75 % increase in survival times of the tumor-bearing animals.

Original languageEnglish
Pages (from-to)303-314
Number of pages12
JournalApplied Magnetic Resonance
Volume45
Issue number4
DOIs
Publication statusPublished - 2014

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gadolinium
rats
fullerenes
magnetic resonance
tumors
water
magnetic relaxation
protons
relaxation time
brain
animals
delivery
augmentation

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Shevtsov, M. A., Nikolaev, B. P., Marchenko, Y. Y., Yakovleva, L. Y., Dobrodumov, A. V., Török, G., ... Lebedev, V. T. (2014). Magnetic Resonance Imaging of Rat C6 Glioma Model Enhanced by Using Water-Soluble Gadolinium Fullerene. Applied Magnetic Resonance, 45(4), 303-314. https://doi.org/10.1007/s00723-014-0519-5

Magnetic Resonance Imaging of Rat C6 Glioma Model Enhanced by Using Water-Soluble Gadolinium Fullerene. / Shevtsov, M. A.; Nikolaev, B. P.; Marchenko, Ya Yu; Yakovleva, L. Y.; Dobrodumov, A. V.; Török, G.; Pitkin, E.; Lebedev, V. T.

In: Applied Magnetic Resonance, Vol. 45, No. 4, 2014, p. 303-314.

Research output: Contribution to journalArticle

Shevtsov, MA, Nikolaev, BP, Marchenko, YY, Yakovleva, LY, Dobrodumov, AV, Török, G, Pitkin, E & Lebedev, VT 2014, 'Magnetic Resonance Imaging of Rat C6 Glioma Model Enhanced by Using Water-Soluble Gadolinium Fullerene', Applied Magnetic Resonance, vol. 45, no. 4, pp. 303-314. https://doi.org/10.1007/s00723-014-0519-5
Shevtsov, M. A. ; Nikolaev, B. P. ; Marchenko, Ya Yu ; Yakovleva, L. Y. ; Dobrodumov, A. V. ; Török, G. ; Pitkin, E. ; Lebedev, V. T. / Magnetic Resonance Imaging of Rat C6 Glioma Model Enhanced by Using Water-Soluble Gadolinium Fullerene. In: Applied Magnetic Resonance. 2014 ; Vol. 45, No. 4. pp. 303-314.
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