Magnetic hyaluronate hydrogels: Preparation and characterization

Ildikó Y. Tóth, Gábor Veress, M. Szekeres, E. Illés, E. Tombácz

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Abstract: A novel soft way of hyaluronate (HyA) based magnetic hydrogel preparation was revealed. Magnetite nanoparticles (MNPs) were prepared by co-precipitation. Since the naked MNPs cannot be dispersed homogenously in HyA-gel, their surface was modified with natural and biocompatible chondroitin-sulfate-A (CSA) to obtain CSA-coated MNPs (CSA@MNPs). The aggregation state of MNPs and that loaded with increasing amount of CSA up to 1 mmol/g was measured by dynamic light scattering at pH~6. Only CSA@MNP with ≥0.2 mmol/g CSA content was suitable for magnetic HyA-gel preparation. Rheological studies showed that the presence of CSA@MNP with up to 2 g/L did not affect the hydrogel's rheological behavior significantly. The results suggest that the HyA-based magnetic hydrogels may be promising formulations for future biomedical applications, e.g. as intra-articular injections in the treatment of osteoarthritis.

Original languageEnglish
Pages (from-to)175-180
Number of pages6
JournalJournal of Magnetism and Magnetic Materials
Volume380
DOIs
Publication statusPublished - Apr 15 2015

Fingerprint

Magnetite Nanoparticles
Magnetite nanoparticles
Hydrogels
Chondroitin Sulfates
magnetite
sulfates
nanoparticles
preparation
Gels
gels
Hydrogel
Dynamic light scattering
Coprecipitation
Sulfates
light scattering
Agglomeration
injection
formulations

Keywords

  • Chondroitin-sulfate-A
  • Hyaluronate
  • Intra-articular injection
  • Magnetic hydrogels
  • Magnetite
  • Surface modification

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials

Cite this

Magnetic hyaluronate hydrogels : Preparation and characterization. / Tóth, Ildikó Y.; Veress, Gábor; Szekeres, M.; Illés, E.; Tombácz, E.

In: Journal of Magnetism and Magnetic Materials, Vol. 380, 15.04.2015, p. 175-180.

Research output: Contribution to journalArticle

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AU - Tóth, Ildikó Y.

AU - Veress, Gábor

AU - Szekeres, M.

AU - Illés, E.

AU - Tombácz, E.

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N2 - Abstract: A novel soft way of hyaluronate (HyA) based magnetic hydrogel preparation was revealed. Magnetite nanoparticles (MNPs) were prepared by co-precipitation. Since the naked MNPs cannot be dispersed homogenously in HyA-gel, their surface was modified with natural and biocompatible chondroitin-sulfate-A (CSA) to obtain CSA-coated MNPs (CSA@MNPs). The aggregation state of MNPs and that loaded with increasing amount of CSA up to 1 mmol/g was measured by dynamic light scattering at pH~6. Only CSA@MNP with ≥0.2 mmol/g CSA content was suitable for magnetic HyA-gel preparation. Rheological studies showed that the presence of CSA@MNP with up to 2 g/L did not affect the hydrogel's rheological behavior significantly. The results suggest that the HyA-based magnetic hydrogels may be promising formulations for future biomedical applications, e.g. as intra-articular injections in the treatment of osteoarthritis.

AB - Abstract: A novel soft way of hyaluronate (HyA) based magnetic hydrogel preparation was revealed. Magnetite nanoparticles (MNPs) were prepared by co-precipitation. Since the naked MNPs cannot be dispersed homogenously in HyA-gel, their surface was modified with natural and biocompatible chondroitin-sulfate-A (CSA) to obtain CSA-coated MNPs (CSA@MNPs). The aggregation state of MNPs and that loaded with increasing amount of CSA up to 1 mmol/g was measured by dynamic light scattering at pH~6. Only CSA@MNP with ≥0.2 mmol/g CSA content was suitable for magnetic HyA-gel preparation. Rheological studies showed that the presence of CSA@MNP with up to 2 g/L did not affect the hydrogel's rheological behavior significantly. The results suggest that the HyA-based magnetic hydrogels may be promising formulations for future biomedical applications, e.g. as intra-articular injections in the treatment of osteoarthritis.

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