Macrocyclic lathyrane diterpenes as antitumor promoters

Rozalia Pusztai, Maria José U. Ferreira, Noélia Duarte, Helga Engi, Joseph Molnar

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20 Citations (Scopus)

Abstract

Human cytomegalovirus (CMV) preferentially infects tumor tissues and the accumulated CMV immediate-early (IE) antigen may lead to tumor promotion and progression. The development of strategies to inhibit human CMV IE antigen expression and/or function is an important goal to prevent and treat certain forms of cancers associated with human CMV. The aim of this study was to search for antitumor promoters from plant sources. The effect of six macrocyclic lathyrane-type diterpenoids, latilagascenes A-E (1-5) and jolkinol B (6), isolated from the methanol extract of Euphorbia lagascae, on the expression of IE antigen in lung cancer cells (A549) infected by CMV was studied. All the compounds, except latilagascene D (4), decreased IE antigen expression of CMV.

Original languageEnglish
Pages (from-to)201-206
Number of pages6
JournalAnticancer research
Volume27
Issue number1 A
Publication statusPublished - Jan 1 2007

Keywords

  • Anti-tumor promoters
  • Euphorbia lagascae
  • Human cytomegalovirus
  • Immediate early-antigen expression
  • Macrocyclic lathyrane diterpenes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Pusztai, R., Ferreira, M. J. U., Duarte, N., Engi, H., & Molnar, J. (2007). Macrocyclic lathyrane diterpenes as antitumor promoters. Anticancer research, 27(1 A), 201-206.