Macrocyclic antibiotic selectors in direct HPLC enantioseparations

I. Ilisz, Zoltán Pataj, Anita Aranyi, A. Péter

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

In the past few decades, macrocyclic antibiotic molecules have become among the most useful chiral selectors in analytical HPLC, thin-layer chromatography and capillary electrophoresis and also in preparative methods. The macrocyclic glycopeptides, such as teicoplanin, vancomycin and ristocetin A and its analogs, are perhaps the most useful selectors for the enantioseparation of nonprotected and N-protected peptides and amino acids, β-blockers, β-agonists, nonsteroidal anti-inflammatory drugs, antineoplastics and various other biologically important compounds. This article discusses the physicochemical properties, method developments, mechanisms and applications for separations on macrocyclic antibiotics. Since comprehensive reviews on the HPLC separation of biologically important analytes on macrocyclic antibiotic chiral stationary phases have been published up to the middle of the 2000s, the recent progress covers the period 2006-2010, focussing on the HPLC applications of antibiotic phases.

Original languageEnglish
Pages (from-to)207-249
Number of pages43
JournalSeparation and Purification Reviews
Volume41
Issue number3
DOIs
Publication statusPublished - Jul 1 2012

Fingerprint

Antibiotics
Anti-Bacterial Agents
Teicoplanin
Thin layer chromatography
Capillary electrophoresis
Glycopeptides
Vancomycin
Antineoplastic Agents
Peptides
Amino acids
Anti-Inflammatory Agents
Amino Acids
Molecules

Keywords

  • chiral chromatography
  • Column liquid chromatography
  • enantiomer separation
  • glycopeptides
  • macrocyclic antibiotics

ASJC Scopus subject areas

  • Analytical Chemistry
  • Filtration and Separation

Cite this

Macrocyclic antibiotic selectors in direct HPLC enantioseparations. / Ilisz, I.; Pataj, Zoltán; Aranyi, Anita; Péter, A.

In: Separation and Purification Reviews, Vol. 41, No. 3, 01.07.2012, p. 207-249.

Research output: Contribution to journalArticle

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