m-CPP-induced self-grooming is mediated by 5-HT2C receptors

Marton Graf, Sandor Kantor, Zsuzsanna E. Anheuer, Edit A. Modos, Gyorgy Bagdy

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

m-Chlorophenylpiperazine (m-CPP), a potent 5-HT receptor agonist, is known to induce self-grooming in rats and exacerbate symptoms in patients with obsessive-compulsive disorder (OCD). To characterise the possible role, 5-HT2B and 5-HT2C receptors play in m-CPP-induced self-grooming, subtype-selective receptor antagonists were used. m-CPP significantly increased the amount of self-grooming in male Sprague-Dawley rats. This effect followed a bell-shaped dose-response curve with a peak at 0.6mg/kg, i.p. Pretreatment with SB-242084, a subtype-selective 5-HT2C receptor antagonist (0.1-0.5mg/kg, i.p.), reversed m-CPP-induced self-grooming. In contrast, pretreatment with the subtype-selective 5-HT2B receptor antagonist SB-215505 (1mg/kg, i.p) did not block the effect of m-CPP. Two days after depletion of brain 5-HT by p-chlorophenylalanine (p-CPA, 2×50, 2×100mg/kg, i.p.) m-CPP-induced responses were significantly enhanced compared to controls. Our studies provide evidence that direct activation of 5-HT2C receptors mediate m-CPP-induced self-grooming and the depletion of brain 5-HT sensitises these receptors.

Original languageEnglish
Pages (from-to)175-179
Number of pages5
JournalBehavioural Brain Research
Volume142
Issue number1-2
DOIs
Publication statusPublished - Jun 16 2003

Keywords

  • 5-HT receptor
  • Obsessive-compulsive disorder
  • SB-215505
  • SB-242084
  • Self-grooming
  • Serotonin
  • m-CPP
  • p-CPA

ASJC Scopus subject areas

  • Behavioral Neuroscience

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