M-chlorophenylpiperazine increases blood pressure and heart rate in pithed and conscious rats

G. Bagdy, Katalin Szemeredi, Zofia Zukowska-Grojec, James Hill, Dennis L. Murphy

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In pithed rats, m-chlorophenylpiperazine (m-CPP) produced marked, dose-dependent (ED50=0.18 μmol) increases in mean arterial blood pressure which peaked within 1 minute and were sustained over 15 minutes. Two serotonin antagonists, metergoline and ritanserin, completely blocked the pressor responses to 2.5 mg/kg m-CPP in pithed adrenal demedullated rats, while alpha-adrenergic blockade by prazosin plus yohimbine was without effect, suggesting that the doubling in blood pressure produced by m-CPP was mediated via serotonin receptors within blood vessels. Somewhat smaller increases in blood pressure over baseline values were observed after m-CPP administration to conscious, freely moving rats. A small but statistically significant increase in heart rate peaked 5 minutes after m-CPP and also was blocked by metergoline but was only minimally affected by ritanserin or the prazosinyohimbine combination. These results with m-CPP support other evidence for two or more separable effects of serotonergic agonists on the peripheral cardiovascular system.

Original languageEnglish
Pages (from-to)775-782
Number of pages8
JournalLife Sciences
Volume41
Issue number6
DOIs
Publication statusPublished - Aug 10 1987

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Blood pressure
Rats
Heart Rate
Blood Pressure
Metergoline
Ritanserin
Arterial Pressure
Cardiovascular system
Serotonin Receptor Agonists
Serotonin Antagonists
Yohimbine
Prazosin
Serotonin Receptors
Blood vessels
Cardiovascular System
Adrenergic Agents
Blood Vessels
1-(3-chlorophenyl)piperazine

ASJC Scopus subject areas

  • Pharmacology

Cite this

M-chlorophenylpiperazine increases blood pressure and heart rate in pithed and conscious rats. / Bagdy, G.; Szemeredi, Katalin; Zukowska-Grojec, Zofia; Hill, James; Murphy, Dennis L.

In: Life Sciences, Vol. 41, No. 6, 10.08.1987, p. 775-782.

Research output: Contribution to journalArticle

Bagdy, G. ; Szemeredi, Katalin ; Zukowska-Grojec, Zofia ; Hill, James ; Murphy, Dennis L. / M-chlorophenylpiperazine increases blood pressure and heart rate in pithed and conscious rats. In: Life Sciences. 1987 ; Vol. 41, No. 6. pp. 775-782.
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