Mössbauer, XRD and TEM Study on the Intercalation and the Release of Drugs in/from Layered Double Hydroxides

E. Kuzmann, V. K. Garg, A. C. De Oliveira, L. Herojit Singh, S. S. Pati, E. M. Guimaraes, Tatiane O. Dos Santos, M. Ádok-Sipiczki, P. Sipos, I. Pálinkó

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Layered double hydroxides (LDHs) are one of the very important nano-carriers for drug delivery, due to their many advantageous features, such as the ease and low-cost of preparation, low cytotoxicity, good biocompatibility, protection for the intercalated drugs, and the capacity to facilitate the uptake of the loaded drug in the cells. In our previous studies, Mössbauer spectroscopy was applied to monitor structural changes occurring during the incorporation of Fe(III) in MgFe- and CaFe-LDHs, and the intercalation of various organic compounds in anionic form. Recently, we have successfully elaborated a protocol for the intercalation and release of indol-2-carboxylate and L-cysteinate in CaFe-LDH. The corresponding structural changes in the LDH samples were studied by XRD, HR-TEM and 57Fe Mössbauer spectroscopy. The Mössbauer spectra reflected small but significant changes upon both the intercalation and the release of drugs. The changes in the basal distances could be followed by XRD measurements, and HR-TEM images made these changes visible.

Original languageEnglish
Pages (from-to)369-376
Number of pages8
JournalCroatica Chemica Acta
Volume88
Issue number4
DOIs
Publication statusPublished - Dec 1 2015

Fingerprint

Hydroxides
Intercalation
Transmission electron microscopy
Pharmaceutical Preparations
Spectroscopy
Cytotoxicity
Drug delivery
Biocompatibility
Organic compounds
Costs

Keywords

  • Drug introduction
  • Drug release
  • HR-TEM
  • Layered double hydroxides
  • Mössbauer spectroscopy
  • XRD

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Mössbauer, XRD and TEM Study on the Intercalation and the Release of Drugs in/from Layered Double Hydroxides. / Kuzmann, E.; Garg, V. K.; De Oliveira, A. C.; Herojit Singh, L.; Pati, S. S.; Guimaraes, E. M.; Dos Santos, Tatiane O.; Ádok-Sipiczki, M.; Sipos, P.; Pálinkó, I.

In: Croatica Chemica Acta, Vol. 88, No. 4, 01.12.2015, p. 369-376.

Research output: Contribution to journalArticle

Kuzmann, E, Garg, VK, De Oliveira, AC, Herojit Singh, L, Pati, SS, Guimaraes, EM, Dos Santos, TO, Ádok-Sipiczki, M, Sipos, P & Pálinkó, I 2015, 'Mössbauer, XRD and TEM Study on the Intercalation and the Release of Drugs in/from Layered Double Hydroxides', Croatica Chemica Acta, vol. 88, no. 4, pp. 369-376. https://doi.org/10.5562/cca2683
Kuzmann, E. ; Garg, V. K. ; De Oliveira, A. C. ; Herojit Singh, L. ; Pati, S. S. ; Guimaraes, E. M. ; Dos Santos, Tatiane O. ; Ádok-Sipiczki, M. ; Sipos, P. ; Pálinkó, I. / Mössbauer, XRD and TEM Study on the Intercalation and the Release of Drugs in/from Layered Double Hydroxides. In: Croatica Chemica Acta. 2015 ; Vol. 88, No. 4. pp. 369-376.
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