Mössbauer study of the effect of pH on Fe valence in iron-polygalacturonate as a medicine for human anaemia

E. Kuzmann, V. K. Garg, A. C. De Oliveira, Z. Klencsár, K. Szentmihályi, J. Fodor, Z. May, Z. Homonnay

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Iron-polygalacturonate complexes have been synthesized from polygalacturonic acid by applying a novel preparation method in order to develop medicine suitable for the effective iron supplementation of the human body in the case of anemia. Since the iron uptake depends on the oxidation state of iron, 57Fe Mössbauer spectroscopy was used to study the occurrence of different valence states in the iron-polygalacturonate complexes prepared under different circumstances. The Mössbauer-spectra indicated the presence of iron both in FeII and FeIII states in the investigated iron-polygalacturonate compounds, the occurrence of which varied with the preparation parameters. A correlation of the relative occurrence of iron valence states with the pH has been found. The relative occurrence of FeIII was found to increase with increasing pH. The knowledge of this correlation can help find optimum preparation conditions of iron-polygalacturonates to cure human anemia.

Original languageEnglish
Pages (from-to)195-198
Number of pages4
JournalRadiation Physics and Chemistry
Volume107
DOIs
Publication statusPublished - Feb 1 2015

Keywords

  • Fe and Fe valence states
  • Fe mössbauer spectroscopy
  • Iron polygalacturonates
  • Medicine for human anemia
  • PH dependence

ASJC Scopus subject areas

  • Radiation

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