Lyotropic liquid crystal preconcentrates for the treatment of periodontal disease

A. Fehér, E. Urbán, I. Eros, P. Szabó-Révész, E. Csányi

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The aim of our study was to develop water-free lyotropic liquid crystalline preconcentrates, which consist of oils and surfactants with good physiological tolerance and spontaneously form lyotropic liquid crystalline phase in aqueous environment. In this way these preconcentrates having low viscosity can be injected into the periodontal pocket, where they are transformed into highly viscous liquid crystalline phase, so that the preparation is prevented from flowing out of the pocket due to its great viscosity, while drug release is controlled by the liquid crystalline texture. In order to follow the structure alteration upon water absorption polarization microscopical and rheological examinations were performed. The water absorption mechanism of the samples was examined by the Enslin-method. Metronidazole-benzoate was used as active agent the release of which was characterized via in vitro investigations performed by means of modified Kirby-Bauer disk diffusion method. On the grounds of the results it can be stated that the 4:1 mixture of the investigated surfactants (Cremophor EL, Cremophor RH40) and oil (Miglyol 810) formed lyotopic liquid crystalline phases upon water addition. Polarization microscopic examinations showed that samples with 10-40% water content possessed anisotropic properties. On the basis of water absorption, rheological and drug release studies it can be concluded that the amount of absorbed water and stiffness of lyotropic structure influenced by the chemical entity of the surfactant exerted major effect on the drug release.

Original languageEnglish
Pages (from-to)23-26
Number of pages4
JournalInternational Journal of Pharmaceutics
Volume358
Issue number1-2
DOIs
Publication statusPublished - Jun 24 2008

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Liquid Crystals
Periodontal Diseases
Water
Surface-Active Agents
Viscosity
Oils
Disk Diffusion Antimicrobial Tests
Periodontal Pocket
Benzoates
Metronidazole

Keywords

  • Drug release
  • Kirby-Bauer disk diffusion method
  • Lyotropic liquid crystals
  • Periodontal disease

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Lyotropic liquid crystal preconcentrates for the treatment of periodontal disease. / Fehér, A.; Urbán, E.; Eros, I.; Szabó-Révész, P.; Csányi, E.

In: International Journal of Pharmaceutics, Vol. 358, No. 1-2, 24.06.2008, p. 23-26.

Research output: Contribution to journalArticle

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