Lymphomák adoleszcens korban: Érdemes-E gyermek-protokollal kezelni ezt a betegcsoportot?

Translated title of the contribution: Lymphomas in adolescents: Are childhood lymphoma therapy protocols suitable for this patient group?

Zsófia Bence, Gábor Kovács, Zsuzsanna Jakab, Monika Csóka, J. Müller

Research output: Contribution to journalArticle

Abstract

The centres of the Hungarian Paediatric Oncology Network annually take care of 250-300 new patients with childhood cancer, every tenth of them suffering from lymphoma. The aim of our work was to analyse the data of the adolescents (14-19 years) with Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL), comparing their survival rates with younger patients under fourteen and with the international data. From January 1990 to December 2004 there were 281 children diagnosed with HL and 230 with NHL. Among the HL patients 107, while among the NHL patients 51 were older than 14 years old. In the group of HL the distribution of patients according to the stage was similar in younger and older patients. In the NHL group 55% of the children younger than 14, and 72% of the patients older than 14 years old had advanced stage disease (stage III or IV). In both groups the patients received chemotherapy according to the current paediatric protocols. The overall survival (OS) of the HL patients younger than 14 was 92.5±2% at 5 years and 90.3±2% at 10 years, and for the adolescents 93.4±2% and 90.7±3% at 5 and 10 years (n.s.). The OS of the younger children in the NHL group was 78.2±3% at 5 and 10 years, and 77.9±6% for the adolescents (n.s.). As a conclusion, survival rates of the adolescents do not differ significantly from the parameters of the patients under fourteen, so the therapy protocols used for childhood lymphomas are suitable for the treatment of the lymphomas appearing at the age of 14-19 years.

Original languageHungarian
Pages (from-to)357-362
Number of pages6
JournalMagyar Onkologia
Volume52
Issue number4
DOIs
Publication statusPublished - 2008

Fingerprint

Lymphoma
Hodgkin Disease
Non-Hodgkin's Lymphoma
Therapeutics
Survival Rate
Pediatrics
Survival
Drug Therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Lymphomák adoleszcens korban : Érdemes-E gyermek-protokollal kezelni ezt a betegcsoportot? / Bence, Zsófia; Kovács, Gábor; Jakab, Zsuzsanna; Csóka, Monika; Müller, J.

In: Magyar Onkologia, Vol. 52, No. 4, 2008, p. 357-362.

Research output: Contribution to journalArticle

Bence, Zsófia ; Kovács, Gábor ; Jakab, Zsuzsanna ; Csóka, Monika ; Müller, J. / Lymphomák adoleszcens korban : Érdemes-E gyermek-protokollal kezelni ezt a betegcsoportot?. In: Magyar Onkologia. 2008 ; Vol. 52, No. 4. pp. 357-362.
@article{5fb6cb6de3804d7d8702be2e25c8e74d,
title = "Lymphom{\'a}k adoleszcens korban: {\'E}rdemes-E gyermek-protokollal kezelni ezt a betegcsoportot?",
abstract = "The centres of the Hungarian Paediatric Oncology Network annually take care of 250-300 new patients with childhood cancer, every tenth of them suffering from lymphoma. The aim of our work was to analyse the data of the adolescents (14-19 years) with Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL), comparing their survival rates with younger patients under fourteen and with the international data. From January 1990 to December 2004 there were 281 children diagnosed with HL and 230 with NHL. Among the HL patients 107, while among the NHL patients 51 were older than 14 years old. In the group of HL the distribution of patients according to the stage was similar in younger and older patients. In the NHL group 55{\%} of the children younger than 14, and 72{\%} of the patients older than 14 years old had advanced stage disease (stage III or IV). In both groups the patients received chemotherapy according to the current paediatric protocols. The overall survival (OS) of the HL patients younger than 14 was 92.5±2{\%} at 5 years and 90.3±2{\%} at 10 years, and for the adolescents 93.4±2{\%} and 90.7±3{\%} at 5 and 10 years (n.s.). The OS of the younger children in the NHL group was 78.2±3{\%} at 5 and 10 years, and 77.9±6{\%} for the adolescents (n.s.). As a conclusion, survival rates of the adolescents do not differ significantly from the parameters of the patients under fourteen, so the therapy protocols used for childhood lymphomas are suitable for the treatment of the lymphomas appearing at the age of 14-19 years.",
keywords = "Adolescent, Hodgkin's lymphoma, Non-Hodgkin's lymphoma, Protocol, Survival",
author = "Zs{\'o}fia Bence and G{\'a}bor Kov{\'a}cs and Zsuzsanna Jakab and Monika Cs{\'o}ka and J. M{\"u}ller",
year = "2008",
doi = "10.1556/MOnkol.52.2008.4.4",
language = "Hungarian",
volume = "52",
pages = "357--362",
journal = "Magyar Onkologia",
issn = "0025-0244",
publisher = "Akademiai Kiado",
number = "4",

}

TY - JOUR

T1 - Lymphomák adoleszcens korban

T2 - Érdemes-E gyermek-protokollal kezelni ezt a betegcsoportot?

AU - Bence, Zsófia

AU - Kovács, Gábor

AU - Jakab, Zsuzsanna

AU - Csóka, Monika

AU - Müller, J.

PY - 2008

Y1 - 2008

N2 - The centres of the Hungarian Paediatric Oncology Network annually take care of 250-300 new patients with childhood cancer, every tenth of them suffering from lymphoma. The aim of our work was to analyse the data of the adolescents (14-19 years) with Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL), comparing their survival rates with younger patients under fourteen and with the international data. From January 1990 to December 2004 there were 281 children diagnosed with HL and 230 with NHL. Among the HL patients 107, while among the NHL patients 51 were older than 14 years old. In the group of HL the distribution of patients according to the stage was similar in younger and older patients. In the NHL group 55% of the children younger than 14, and 72% of the patients older than 14 years old had advanced stage disease (stage III or IV). In both groups the patients received chemotherapy according to the current paediatric protocols. The overall survival (OS) of the HL patients younger than 14 was 92.5±2% at 5 years and 90.3±2% at 10 years, and for the adolescents 93.4±2% and 90.7±3% at 5 and 10 years (n.s.). The OS of the younger children in the NHL group was 78.2±3% at 5 and 10 years, and 77.9±6% for the adolescents (n.s.). As a conclusion, survival rates of the adolescents do not differ significantly from the parameters of the patients under fourteen, so the therapy protocols used for childhood lymphomas are suitable for the treatment of the lymphomas appearing at the age of 14-19 years.

AB - The centres of the Hungarian Paediatric Oncology Network annually take care of 250-300 new patients with childhood cancer, every tenth of them suffering from lymphoma. The aim of our work was to analyse the data of the adolescents (14-19 years) with Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL), comparing their survival rates with younger patients under fourteen and with the international data. From January 1990 to December 2004 there were 281 children diagnosed with HL and 230 with NHL. Among the HL patients 107, while among the NHL patients 51 were older than 14 years old. In the group of HL the distribution of patients according to the stage was similar in younger and older patients. In the NHL group 55% of the children younger than 14, and 72% of the patients older than 14 years old had advanced stage disease (stage III or IV). In both groups the patients received chemotherapy according to the current paediatric protocols. The overall survival (OS) of the HL patients younger than 14 was 92.5±2% at 5 years and 90.3±2% at 10 years, and for the adolescents 93.4±2% and 90.7±3% at 5 and 10 years (n.s.). The OS of the younger children in the NHL group was 78.2±3% at 5 and 10 years, and 77.9±6% for the adolescents (n.s.). As a conclusion, survival rates of the adolescents do not differ significantly from the parameters of the patients under fourteen, so the therapy protocols used for childhood lymphomas are suitable for the treatment of the lymphomas appearing at the age of 14-19 years.

KW - Adolescent

KW - Hodgkin's lymphoma

KW - Non-Hodgkin's lymphoma

KW - Protocol

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=59849108149&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=59849108149&partnerID=8YFLogxK

U2 - 10.1556/MOnkol.52.2008.4.4

DO - 10.1556/MOnkol.52.2008.4.4

M3 - Article

C2 - 19068463

AN - SCOPUS:59849108149

VL - 52

SP - 357

EP - 362

JO - Magyar Onkologia

JF - Magyar Onkologia

SN - 0025-0244

IS - 4

ER -