Lymphocytic progesterone receptors in normal and pathological human pregnancy

Julia Szekeres-Bartho, M. F. Reznikoff-Etievant, P. Varga, M. F. Pichon, Z. Varga, G. Chaouat

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61 Citations (Scopus)

Abstract

The progesterone receptor-specific monoclonal antibody (MoAb) mPRI was tested for its reactivity towards peripheral blood lymphocytes (PBL) of 49 healthy pregnant women, nine pregnant women with clinical symptoms of threatened preterm delivery, seven women with recurrent spontaneous abortion, ten women in labour and ten women with spontaneous abortion. Lymphocytes of 12 healthy age-matched non-pregnant volunteers were used as controls. Lymphocytes of nine healthy pregnant women at the 1st trimester of pregnancy and those of two non-pregnant donors were tested for the presence of estrogen and progesterone receptors by enzyme immunoassay. PBL of healthy pregnant women contained significantly more positive cells than those of non-pregnant controls. Furthermore, the number of receptor-containing cells increased in parallel with gestational age. In blood samples drawn during labour, as well as in those obtained from women with spontaneous abortion or clinical symptoms of threatened pre-term delivery, the percentage of positively stained lymphocytes was significantly lower than normal pregnancy values. This was also the case in peripheral blood of pregnant women with a history of recurrent spontaneous abortions.

Original languageEnglish
Pages (from-to)239-247
Number of pages9
JournalJournal of Reproductive Immunology
Volume16
Issue number3
DOIs
Publication statusPublished - Dec 1989

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Keywords

  • abortion
  • human pregnancy
  • peripheral blood lyphocytes
  • progesterone receptors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynaecology

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