Lymphocytes resided in the thyroid are the main source of TSH-receptor antibodies in Basedow's-Graves' disease?

A. Leovey, E. Nagy, G. Balazs, G. Bako

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The source of TSH-receptor antibodies (TRAb) in Basedow's-Graves' disease is still under debate. Previous studies by other groups had found TRAb levels in the thyroid vein higher than or equal to that in the peripheral vein. The aim of the present work was to investigate the suspected presence of this TRAb gradient in 14 Graves' patients who underwent surgery. Interestingly, in 6 patients higher levels of TRAb were measured in the antecubital vein when compared to the thyroid vein, in another 6 there was no gradient and 2 exhibited higher TRAb levels in their thyroid veins. A clear gradient of thyroid hormones in favour of the thyroid vein was also present, while no gradient of TSH, anti-thyreoglobulin and anti-microsomal antibodies, total IgG, IgA and IgM levels and no differences of the CD4+/CD8+ cell ratios were found between the two sampling sites. We conclude that cells other than lymphocytes residing in the thyroid gland must also be involved in TRAb production.

Original languageEnglish
Pages (from-to)147-150
Number of pages4
JournalExperimental and Clinical Endocrinology
Volume99
Issue number3
Publication statusPublished - 1992

Fingerprint

Graves Disease
Veins
Thyroid Gland
Lymphocytes
CD4-CD8 Ratio
Thyroid Hormones
Immunoglobulin A
Antibody Formation
Immunoglobulin M
thyrotropin-binding inhibitory immunoglobulin
Anti-Idiotypic Antibodies
Immunoglobulin G

Keywords

  • Graves' disease
  • Thyroidectomy
  • TRAb

ASJC Scopus subject areas

  • Endocrinology

Cite this

Lymphocytes resided in the thyroid are the main source of TSH-receptor antibodies in Basedow's-Graves' disease? / Leovey, A.; Nagy, E.; Balazs, G.; Bako, G.

In: Experimental and Clinical Endocrinology, Vol. 99, No. 3, 1992, p. 147-150.

Research output: Contribution to journalArticle

@article{f4b872a7a3744a3897790028197de135,
title = "Lymphocytes resided in the thyroid are the main source of TSH-receptor antibodies in Basedow's-Graves' disease?",
abstract = "The source of TSH-receptor antibodies (TRAb) in Basedow's-Graves' disease is still under debate. Previous studies by other groups had found TRAb levels in the thyroid vein higher than or equal to that in the peripheral vein. The aim of the present work was to investigate the suspected presence of this TRAb gradient in 14 Graves' patients who underwent surgery. Interestingly, in 6 patients higher levels of TRAb were measured in the antecubital vein when compared to the thyroid vein, in another 6 there was no gradient and 2 exhibited higher TRAb levels in their thyroid veins. A clear gradient of thyroid hormones in favour of the thyroid vein was also present, while no gradient of TSH, anti-thyreoglobulin and anti-microsomal antibodies, total IgG, IgA and IgM levels and no differences of the CD4+/CD8+ cell ratios were found between the two sampling sites. We conclude that cells other than lymphocytes residing in the thyroid gland must also be involved in TRAb production.",
keywords = "Graves' disease, Thyroidectomy, TRAb",
author = "A. Leovey and E. Nagy and G. Balazs and G. Bako",
year = "1992",
language = "English",
volume = "99",
pages = "147--150",
journal = "Experimental and Clinical Endocrinology and Diabetes",
issn = "0947-7349",
publisher = "Thieme",
number = "3",

}

TY - JOUR

T1 - Lymphocytes resided in the thyroid are the main source of TSH-receptor antibodies in Basedow's-Graves' disease?

AU - Leovey, A.

AU - Nagy, E.

AU - Balazs, G.

AU - Bako, G.

PY - 1992

Y1 - 1992

N2 - The source of TSH-receptor antibodies (TRAb) in Basedow's-Graves' disease is still under debate. Previous studies by other groups had found TRAb levels in the thyroid vein higher than or equal to that in the peripheral vein. The aim of the present work was to investigate the suspected presence of this TRAb gradient in 14 Graves' patients who underwent surgery. Interestingly, in 6 patients higher levels of TRAb were measured in the antecubital vein when compared to the thyroid vein, in another 6 there was no gradient and 2 exhibited higher TRAb levels in their thyroid veins. A clear gradient of thyroid hormones in favour of the thyroid vein was also present, while no gradient of TSH, anti-thyreoglobulin and anti-microsomal antibodies, total IgG, IgA and IgM levels and no differences of the CD4+/CD8+ cell ratios were found between the two sampling sites. We conclude that cells other than lymphocytes residing in the thyroid gland must also be involved in TRAb production.

AB - The source of TSH-receptor antibodies (TRAb) in Basedow's-Graves' disease is still under debate. Previous studies by other groups had found TRAb levels in the thyroid vein higher than or equal to that in the peripheral vein. The aim of the present work was to investigate the suspected presence of this TRAb gradient in 14 Graves' patients who underwent surgery. Interestingly, in 6 patients higher levels of TRAb were measured in the antecubital vein when compared to the thyroid vein, in another 6 there was no gradient and 2 exhibited higher TRAb levels in their thyroid veins. A clear gradient of thyroid hormones in favour of the thyroid vein was also present, while no gradient of TSH, anti-thyreoglobulin and anti-microsomal antibodies, total IgG, IgA and IgM levels and no differences of the CD4+/CD8+ cell ratios were found between the two sampling sites. We conclude that cells other than lymphocytes residing in the thyroid gland must also be involved in TRAb production.

KW - Graves' disease

KW - Thyroidectomy

KW - TRAb

UR - http://www.scopus.com/inward/record.url?scp=0026802899&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026802899&partnerID=8YFLogxK

M3 - Article

C2 - 1526264

AN - SCOPUS:0026802899

VL - 99

SP - 147

EP - 150

JO - Experimental and Clinical Endocrinology and Diabetes

JF - Experimental and Clinical Endocrinology and Diabetes

SN - 0947-7349

IS - 3

ER -