Lymphocyte subsets in pediatric migraine

Aron Cseh, Kristof Mark Farkas, Laszlo Derzbach, Katalin Muller, Barna Vasarhelyi, Balazs Szalay, Andras Treszl, Viktor Farkas

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8 Citations (Scopus)


Aseptic inflammation due to activated immune cells has been implicated in the pathomechanism of migraine. We measured the prevalence of regulatory T cells (Tregs), along with that of CD4+/CD8+ lymphocytes and their Th1/Th2 commitment in pediatric migraine. Children and adolescents suffering from migraine without aura, migraine with aura and hemiplegic migraine ictally (n = 53, 27, and 20, respectively), also interictally (n = 33) were recruited and compared to 24 healthy children. Our results indicated comparable prevalence of Tregs, CD4+ and Th1/Th2 committed cells. CD8 + prevalence was lower, and CD4+/CD8+ ratio was higher in ictal phase irrespective of the subtype of migraine. No association between CD8+ prevalence and gender, body weight, disease onset and attack duration in migraine subtypes was found. CD8+ prevalence was normal in patients in interictal phase. These results suggest the absence of major systemic alteration of adaptive immunity in children and adolescents suffering from migraine; however, a transient decrease of CD8+ prevalence during the ictal phase was detected irrespective of the subtype of migraine.

Original languageEnglish
Pages (from-to)1151-1155
Number of pages5
JournalNeurological Sciences
Issue number7
Publication statusPublished - Jul 1 2013


  • Adolescence
  • Childhood
  • Lymphocytes
  • Migraine
  • Regulatory T cells

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

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  • Cite this

    Cseh, A., Farkas, K. M., Derzbach, L., Muller, K., Vasarhelyi, B., Szalay, B., Treszl, A., & Farkas, V. (2013). Lymphocyte subsets in pediatric migraine. Neurological Sciences, 34(7), 1151-1155.