Lymphocyte responsiveness of pregnant women after glucocorticoid prophylaxis for respiratory distress syndrome

J. Hadnagy, J. Szekeres Bartho, V. Csernus, S. A. Pacsa

Research output: Contribution to journalArticle

Abstract

For investigating the side effects of steroid prophylaxis for respiratory distress syndrome on the maternal immune system cytotoxic activity and the progesterone binding capacity of lymphocytes from 30 pregnant women were determined. The same parameters of lymphocyte function were also determined in untreated healthy pregnant women. Lymphocytes became significantly less cytotoxic (p < 0.001) and were able to bind significantly more progesterone (p < 0.001) after the steroid treatment, so in this respect their behavior became similar to that of lymphocytes obtained from healthy pregnant women. As this treatment did not suppress lymphocyte cytotoxicity beyond the normal level, impaired lymphocyte function may not contribute to the increased risk of acquiring intrauterine infections.

Original languageEnglish
Pages (from-to)544-545
Number of pages2
JournalIRCS Medical Science
Volume11
Issue number6
Publication statusPublished - Jan 1 1983

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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