LYMPHOBLASTIC TRANSFORMATION, CHROMOSOME PATTERN AND DELAYED‐TYPE SKIN REACTION IN ATAXIA TELANGIECTASIA

D. SCHULER, L. SCHöNGUT, E. CSERHATI, J. SIEGLER, G. GÁCS

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In 6 patients suffering from ataxia telangiectasia morphological evaluation of lymphoblastic transformation was performed; in one of these cases it was repeated four times. In 3 cases the incorporation of 3H‐thymidine was measured to examine the degree of the lymphoblastic transformation. Both methods revealed decreased lymphoblastic transformation, though with the last method the decrease was much greater. No correlation was found between the degree of decreased blastic transformation, the infections and the plasma IgA level. Delayed‐type skin reactions were subnormal in varying degrees. Increased frequency of chromosome breakage was observed in 1 case–who developed malignancy and died– but no chromosomal aberrations were found in the three other cytogenetically examined patients.

Original languageEnglish
Pages (from-to)66-72
Number of pages7
JournalActa Pædiatrica
Volume60
Issue number1
DOIs
Publication statusPublished - Jan 1971

Keywords

  • Ataxia telangiectasia
  • chromosome pattern
  • delayed‐type skin reaction
  • lymphoblastic transformation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'LYMPHOBLASTIC TRANSFORMATION, CHROMOSOME PATTERN AND DELAYED‐TYPE SKIN REACTION IN ATAXIA TELANGIECTASIA'. Together they form a unique fingerprint.

  • Cite this