Luteinizing hormone-releasing hormone antagonists

Gbor Mezo, Marilena Manea

Research output: Contribution to journalReview article

14 Citations (Scopus)


Background: Luteinizing hormone-releasing hormone (LH-RH) plays a central role in the vertebrate reproduction by regulating gonadal activity. Based on its binding to pituitary LH-RH receptors, as well as to LH-RH receptors expressed on cancer cells, LH-RH agonists and antagonists have been developed for different therapeutic applications. Objective/method: Here we give an overview of the most relevant LH-RH antagonists and their therapeutic applications. Recently patented compounds as well as drug formulations and dosage are presented. Conclusion: LH-RH antagonists have found clinical applications in in vitro fertilization, benign prostatic hyperplasia, endometriosis and in the treatment of hormone-dependent tumors. Work in progress is focused on further development of both peptidic and orally active non-peptidic LH-RH antagonists.

Original languageEnglish
Pages (from-to)1771-1785
Number of pages15
JournalExpert Opinion on Therapeutic Patents
Issue number12
Publication statusPublished - Dec 1 2009


  • Gonadotropin-releasing hormone
  • Hormone-dependent tumors
  • In vitro fertilization
  • LH-RH antagonists
  • Luteinizing hormone-releasing hormone
  • Non-peptidic LH-RH antagonists
  • Tumor therapy

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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