Abstract
Purpose: To test whether serum inhibin levels are related to differences in gonadotropin concentrations between patients with an elevated LH-to-FSH ratio (ELF patients) and controls. Methods: 32 ELF patients were matched with controls by age, body mass index (BMI), and cycle length. Results: No statistically significant difference was found in follicular-phase inhibin B levels or midluteal inhibin A levels between cases and controls. Significant negative correlation was observed between follicular-phase inhibin B concentrations and BMI in ELF patients but not among controls. LH and FSH were positively related to inhibin B levels in ELF patients. Midluteal inhibin A correlated with sex hormone-binding globulin in controls but not in ELF patients. Conclusions: Neither follicular-phase inhibin B levels nor midluteal inhibin A levels are characteristic of patients with an elevated LH-to-FSH ratio. Opposite correlations with LH and BMI suggest dysregulation of inhibin secretion rather than dimeric inhibins having a central role to the endocrinological imbalance observed in polycystic ovary syndrome.
| Original language | English |
|---|---|
| Pages (from-to) | 141-147 |
| Number of pages | 7 |
| Journal | Journal of Assisted Reproduction and Genetics |
| Volume | 23 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2006 |
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Keywords
- FSH
- Inhibin A
- Inhibin B
- LH
- Polycystic ovary syndrome
ASJC Scopus subject areas
- Obstetrics and Gynaecology
- Developmental Biology
- Genetics
- Reproductive Medicine
Cite this
Luteal-phase inhibin A and follicular-phase inhibin B levels are not characteristic of patients with an elevated LH-to-FSH ratio. / Hauzman, Erik E.; Fancsovits, Péter; Murber, Ákos; Rabe, Thomas; Strowitzki, Thomas; Papp, Z.; Urbancsek, J.
In: Journal of Assisted Reproduction and Genetics, Vol. 23, No. 3, 03.2006, p. 141-147.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Luteal-phase inhibin A and follicular-phase inhibin B levels are not characteristic of patients with an elevated LH-to-FSH ratio
AU - Hauzman, Erik E.
AU - Fancsovits, Péter
AU - Murber, Ákos
AU - Rabe, Thomas
AU - Strowitzki, Thomas
AU - Papp, Z.
AU - Urbancsek, J.
PY - 2006/3
Y1 - 2006/3
N2 - Purpose: To test whether serum inhibin levels are related to differences in gonadotropin concentrations between patients with an elevated LH-to-FSH ratio (ELF patients) and controls. Methods: 32 ELF patients were matched with controls by age, body mass index (BMI), and cycle length. Results: No statistically significant difference was found in follicular-phase inhibin B levels or midluteal inhibin A levels between cases and controls. Significant negative correlation was observed between follicular-phase inhibin B concentrations and BMI in ELF patients but not among controls. LH and FSH were positively related to inhibin B levels in ELF patients. Midluteal inhibin A correlated with sex hormone-binding globulin in controls but not in ELF patients. Conclusions: Neither follicular-phase inhibin B levels nor midluteal inhibin A levels are characteristic of patients with an elevated LH-to-FSH ratio. Opposite correlations with LH and BMI suggest dysregulation of inhibin secretion rather than dimeric inhibins having a central role to the endocrinological imbalance observed in polycystic ovary syndrome.
AB - Purpose: To test whether serum inhibin levels are related to differences in gonadotropin concentrations between patients with an elevated LH-to-FSH ratio (ELF patients) and controls. Methods: 32 ELF patients were matched with controls by age, body mass index (BMI), and cycle length. Results: No statistically significant difference was found in follicular-phase inhibin B levels or midluteal inhibin A levels between cases and controls. Significant negative correlation was observed between follicular-phase inhibin B concentrations and BMI in ELF patients but not among controls. LH and FSH were positively related to inhibin B levels in ELF patients. Midluteal inhibin A correlated with sex hormone-binding globulin in controls but not in ELF patients. Conclusions: Neither follicular-phase inhibin B levels nor midluteal inhibin A levels are characteristic of patients with an elevated LH-to-FSH ratio. Opposite correlations with LH and BMI suggest dysregulation of inhibin secretion rather than dimeric inhibins having a central role to the endocrinological imbalance observed in polycystic ovary syndrome.
KW - FSH
KW - Inhibin A
KW - Inhibin B
KW - LH
KW - Polycystic ovary syndrome
UR - http://www.scopus.com/inward/record.url?scp=33745048484&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745048484&partnerID=8YFLogxK
U2 - 10.1007/s10815-006-9043-3
DO - 10.1007/s10815-006-9043-3
M3 - Article
C2 - 16758344
AN - SCOPUS:33745048484
VL - 23
SP - 141
EP - 147
JO - Journal of Assisted Reproduction and Genetics
JF - Journal of Assisted Reproduction and Genetics
SN - 1058-0468
IS - 3
ER -