Luteal-phase inhibin A and follicular-phase inhibin B levels are not characteristic of patients with an elevated LH-to-FSH ratio

Erik E. Hauzman, Péter Fancsovits, Ákos Murber, Thomas Rabe, Thomas Strowitzki, Z. Papp, J. Urbancsek

Research output: Contribution to journalArticle

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Abstract

Purpose: To test whether serum inhibin levels are related to differences in gonadotropin concentrations between patients with an elevated LH-to-FSH ratio (ELF patients) and controls. Methods: 32 ELF patients were matched with controls by age, body mass index (BMI), and cycle length. Results: No statistically significant difference was found in follicular-phase inhibin B levels or midluteal inhibin A levels between cases and controls. Significant negative correlation was observed between follicular-phase inhibin B concentrations and BMI in ELF patients but not among controls. LH and FSH were positively related to inhibin B levels in ELF patients. Midluteal inhibin A correlated with sex hormone-binding globulin in controls but not in ELF patients. Conclusions: Neither follicular-phase inhibin B levels nor midluteal inhibin A levels are characteristic of patients with an elevated LH-to-FSH ratio. Opposite correlations with LH and BMI suggest dysregulation of inhibin secretion rather than dimeric inhibins having a central role to the endocrinological imbalance observed in polycystic ovary syndrome.

Original languageEnglish
Pages (from-to)141-147
Number of pages7
JournalJournal of Assisted Reproduction and Genetics
Volume23
Issue number3
DOIs
Publication statusPublished - Mar 2006

Fingerprint

Follicular Phase
Luteal Phase
Inhibins
Body Mass Index
Sex Hormone-Binding Globulin
Polycystic Ovary Syndrome
inhibin A
inhibin B
Gonadotropins
Serum

Keywords

  • FSH
  • Inhibin A
  • Inhibin B
  • LH
  • Polycystic ovary syndrome

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Developmental Biology
  • Genetics
  • Reproductive Medicine

Cite this

Luteal-phase inhibin A and follicular-phase inhibin B levels are not characteristic of patients with an elevated LH-to-FSH ratio. / Hauzman, Erik E.; Fancsovits, Péter; Murber, Ákos; Rabe, Thomas; Strowitzki, Thomas; Papp, Z.; Urbancsek, J.

In: Journal of Assisted Reproduction and Genetics, Vol. 23, No. 3, 03.2006, p. 141-147.

Research output: Contribution to journalArticle

Hauzman, Erik E. ; Fancsovits, Péter ; Murber, Ákos ; Rabe, Thomas ; Strowitzki, Thomas ; Papp, Z. ; Urbancsek, J. / Luteal-phase inhibin A and follicular-phase inhibin B levels are not characteristic of patients with an elevated LH-to-FSH ratio. In: Journal of Assisted Reproduction and Genetics. 2006 ; Vol. 23, No. 3. pp. 141-147.
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