Lung cancer susceptibility locus at 5p15.33

James D. McKay, Rayjean J. Hung, Valerie Gaborieau, Paolo Boffetta, Amelie Chabrier, Graham Byrnes, David Zaridze, Anush Mukeria, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska, P. Rudnai, Eleonora Fabianova, Dana Mates, Vladimir Bencko, Lenka Foretova, Vladimir Janout, John McLaughlin, Frances Shepherd, Alexandre Montpetit, Steven NarodHans E. Krokan, Frank Skorpen, Maiken Bratt Elvestad, Lars Vatten, Inger Njølstad, Tomas Axelsson, Chu Chen, Gary Goodman, Matt Barnett, Melissa M. Loomis, Jan Lubĩski, Joanna Matyjasik, Marcin Lener, Dorota Oszutowska, John Field, Triantafillos Liloglou, George Xinarianos, Adrian Cassidy, Diana Zelenika, Anne Boland, Marc Delepine, Mario Foglio, Doris Lechner, Fumihiko Matsuda, Helene Blanche, Ivo Gut, Simon Heath, Mark Lathrop, Paul Brennan, Paolo Vineis, Francoise Clavel-Chapelon, Domenico Palli, Rosario Tumino, Vittorio Krogh, Salvatore Panico, Carlos A. González, José Ramón Quirós, Carmen Martínez, Carmen Navarro, Eva Ardanaz, Nerea Larrãaga, Kay Tee Kham, Timothy Key, H. Bas Bueno-De-Mesquita, Petra H M Peeters, Antonia Trichopoulou, Jakob Linseisen, Heiner Boeing, Göran Hallmans, Kim Overvad, Anne Tjønneland, Merethe Kumle, Elio Riboli

Research output: Contribution to journalArticle

417 Citations (Scopus)

Abstract

We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P = 2 × 10-7 and P = 4 × 10-6) and replicated by the independent study series (P = 7 × 10-5 and P = 0.016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology.

Original languageEnglish
Pages (from-to)1404-1406
Number of pages3
JournalNature Genetics
Volume40
Issue number12
DOIs
Publication statusPublished - Dec 2008

Fingerprint

Lung Neoplasms
Genome-Wide Association Study
Genome
Genes

ASJC Scopus subject areas

  • Genetics

Cite this

McKay, J. D., Hung, R. J., Gaborieau, V., Boffetta, P., Chabrier, A., Byrnes, G., ... Riboli, E. (2008). Lung cancer susceptibility locus at 5p15.33. Nature Genetics, 40(12), 1404-1406. https://doi.org/10.1038/ng.254

Lung cancer susceptibility locus at 5p15.33. / McKay, James D.; Hung, Rayjean J.; Gaborieau, Valerie; Boffetta, Paolo; Chabrier, Amelie; Byrnes, Graham; Zaridze, David; Mukeria, Anush; Szeszenia-Dabrowska, Neonilia; Lissowska, Jolanta; Rudnai, P.; Fabianova, Eleonora; Mates, Dana; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; McLaughlin, John; Shepherd, Frances; Montpetit, Alexandre; Narod, Steven; Krokan, Hans E.; Skorpen, Frank; Elvestad, Maiken Bratt; Vatten, Lars; Njølstad, Inger; Axelsson, Tomas; Chen, Chu; Goodman, Gary; Barnett, Matt; Loomis, Melissa M.; Lubĩski, Jan; Matyjasik, Joanna; Lener, Marcin; Oszutowska, Dorota; Field, John; Liloglou, Triantafillos; Xinarianos, George; Cassidy, Adrian; Zelenika, Diana; Boland, Anne; Delepine, Marc; Foglio, Mario; Lechner, Doris; Matsuda, Fumihiko; Blanche, Helene; Gut, Ivo; Heath, Simon; Lathrop, Mark; Brennan, Paul; Vineis, Paolo; Clavel-Chapelon, Francoise; Palli, Domenico; Tumino, Rosario; Krogh, Vittorio; Panico, Salvatore; González, Carlos A.; Ramón Quirós, José; Martínez, Carmen; Navarro, Carmen; Ardanaz, Eva; Larrãaga, Nerea; Kham, Kay Tee; Key, Timothy; Bueno-De-Mesquita, H. Bas; Peeters, Petra H M; Trichopoulou, Antonia; Linseisen, Jakob; Boeing, Heiner; Hallmans, Göran; Overvad, Kim; Tjønneland, Anne; Kumle, Merethe; Riboli, Elio.

In: Nature Genetics, Vol. 40, No. 12, 12.2008, p. 1404-1406.

Research output: Contribution to journalArticle

McKay, JD, Hung, RJ, Gaborieau, V, Boffetta, P, Chabrier, A, Byrnes, G, Zaridze, D, Mukeria, A, Szeszenia-Dabrowska, N, Lissowska, J, Rudnai, P, Fabianova, E, Mates, D, Bencko, V, Foretova, L, Janout, V, McLaughlin, J, Shepherd, F, Montpetit, A, Narod, S, Krokan, HE, Skorpen, F, Elvestad, MB, Vatten, L, Njølstad, I, Axelsson, T, Chen, C, Goodman, G, Barnett, M, Loomis, MM, Lubĩski, J, Matyjasik, J, Lener, M, Oszutowska, D, Field, J, Liloglou, T, Xinarianos, G, Cassidy, A, Zelenika, D, Boland, A, Delepine, M, Foglio, M, Lechner, D, Matsuda, F, Blanche, H, Gut, I, Heath, S, Lathrop, M, Brennan, P, Vineis, P, Clavel-Chapelon, F, Palli, D, Tumino, R, Krogh, V, Panico, S, González, CA, Ramón Quirós, J, Martínez, C, Navarro, C, Ardanaz, E, Larrãaga, N, Kham, KT, Key, T, Bueno-De-Mesquita, HB, Peeters, PHM, Trichopoulou, A, Linseisen, J, Boeing, H, Hallmans, G, Overvad, K, Tjønneland, A, Kumle, M & Riboli, E 2008, 'Lung cancer susceptibility locus at 5p15.33', Nature Genetics, vol. 40, no. 12, pp. 1404-1406. https://doi.org/10.1038/ng.254
McKay JD, Hung RJ, Gaborieau V, Boffetta P, Chabrier A, Byrnes G et al. Lung cancer susceptibility locus at 5p15.33. Nature Genetics. 2008 Dec;40(12):1404-1406. https://doi.org/10.1038/ng.254
McKay, James D. ; Hung, Rayjean J. ; Gaborieau, Valerie ; Boffetta, Paolo ; Chabrier, Amelie ; Byrnes, Graham ; Zaridze, David ; Mukeria, Anush ; Szeszenia-Dabrowska, Neonilia ; Lissowska, Jolanta ; Rudnai, P. ; Fabianova, Eleonora ; Mates, Dana ; Bencko, Vladimir ; Foretova, Lenka ; Janout, Vladimir ; McLaughlin, John ; Shepherd, Frances ; Montpetit, Alexandre ; Narod, Steven ; Krokan, Hans E. ; Skorpen, Frank ; Elvestad, Maiken Bratt ; Vatten, Lars ; Njølstad, Inger ; Axelsson, Tomas ; Chen, Chu ; Goodman, Gary ; Barnett, Matt ; Loomis, Melissa M. ; Lubĩski, Jan ; Matyjasik, Joanna ; Lener, Marcin ; Oszutowska, Dorota ; Field, John ; Liloglou, Triantafillos ; Xinarianos, George ; Cassidy, Adrian ; Zelenika, Diana ; Boland, Anne ; Delepine, Marc ; Foglio, Mario ; Lechner, Doris ; Matsuda, Fumihiko ; Blanche, Helene ; Gut, Ivo ; Heath, Simon ; Lathrop, Mark ; Brennan, Paul ; Vineis, Paolo ; Clavel-Chapelon, Francoise ; Palli, Domenico ; Tumino, Rosario ; Krogh, Vittorio ; Panico, Salvatore ; González, Carlos A. ; Ramón Quirós, José ; Martínez, Carmen ; Navarro, Carmen ; Ardanaz, Eva ; Larrãaga, Nerea ; Kham, Kay Tee ; Key, Timothy ; Bueno-De-Mesquita, H. Bas ; Peeters, Petra H M ; Trichopoulou, Antonia ; Linseisen, Jakob ; Boeing, Heiner ; Hallmans, Göran ; Overvad, Kim ; Tjønneland, Anne ; Kumle, Merethe ; Riboli, Elio. / Lung cancer susceptibility locus at 5p15.33. In: Nature Genetics. 2008 ; Vol. 40, No. 12. pp. 1404-1406.
@article{fb949faf21ce431b9f49c67e88c610fc,
title = "Lung cancer susceptibility locus at 5p15.33",
abstract = "We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P = 2 × 10-7 and P = 4 × 10-6) and replicated by the independent study series (P = 7 × 10-5 and P = 0.016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology.",
author = "McKay, {James D.} and Hung, {Rayjean J.} and Valerie Gaborieau and Paolo Boffetta and Amelie Chabrier and Graham Byrnes and David Zaridze and Anush Mukeria and Neonilia Szeszenia-Dabrowska and Jolanta Lissowska and P. Rudnai and Eleonora Fabianova and Dana Mates and Vladimir Bencko and Lenka Foretova and Vladimir Janout and John McLaughlin and Frances Shepherd and Alexandre Montpetit and Steven Narod and Krokan, {Hans E.} and Frank Skorpen and Elvestad, {Maiken Bratt} and Lars Vatten and Inger Nj{\o}lstad and Tomas Axelsson and Chu Chen and Gary Goodman and Matt Barnett and Loomis, {Melissa M.} and Jan Lubĩski and Joanna Matyjasik and Marcin Lener and Dorota Oszutowska and John Field and Triantafillos Liloglou and George Xinarianos and Adrian Cassidy and Diana Zelenika and Anne Boland and Marc Delepine and Mario Foglio and Doris Lechner and Fumihiko Matsuda and Helene Blanche and Ivo Gut and Simon Heath and Mark Lathrop and Paul Brennan and Paolo Vineis and Francoise Clavel-Chapelon and Domenico Palli and Rosario Tumino and Vittorio Krogh and Salvatore Panico and Gonz{\'a}lez, {Carlos A.} and {Ram{\'o}n Quir{\'o}s}, Jos{\'e} and Carmen Mart{\'i}nez and Carmen Navarro and Eva Ardanaz and Nerea Larr{\~a}aga and Kham, {Kay Tee} and Timothy Key and Bueno-De-Mesquita, {H. Bas} and Peeters, {Petra H M} and Antonia Trichopoulou and Jakob Linseisen and Heiner Boeing and G{\"o}ran Hallmans and Kim Overvad and Anne Tj{\o}nneland and Merethe Kumle and Elio Riboli",
year = "2008",
month = "12",
doi = "10.1038/ng.254",
language = "English",
volume = "40",
pages = "1404--1406",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "12",

}

TY - JOUR

T1 - Lung cancer susceptibility locus at 5p15.33

AU - McKay, James D.

AU - Hung, Rayjean J.

AU - Gaborieau, Valerie

AU - Boffetta, Paolo

AU - Chabrier, Amelie

AU - Byrnes, Graham

AU - Zaridze, David

AU - Mukeria, Anush

AU - Szeszenia-Dabrowska, Neonilia

AU - Lissowska, Jolanta

AU - Rudnai, P.

AU - Fabianova, Eleonora

AU - Mates, Dana

AU - Bencko, Vladimir

AU - Foretova, Lenka

AU - Janout, Vladimir

AU - McLaughlin, John

AU - Shepherd, Frances

AU - Montpetit, Alexandre

AU - Narod, Steven

AU - Krokan, Hans E.

AU - Skorpen, Frank

AU - Elvestad, Maiken Bratt

AU - Vatten, Lars

AU - Njølstad, Inger

AU - Axelsson, Tomas

AU - Chen, Chu

AU - Goodman, Gary

AU - Barnett, Matt

AU - Loomis, Melissa M.

AU - Lubĩski, Jan

AU - Matyjasik, Joanna

AU - Lener, Marcin

AU - Oszutowska, Dorota

AU - Field, John

AU - Liloglou, Triantafillos

AU - Xinarianos, George

AU - Cassidy, Adrian

AU - Zelenika, Diana

AU - Boland, Anne

AU - Delepine, Marc

AU - Foglio, Mario

AU - Lechner, Doris

AU - Matsuda, Fumihiko

AU - Blanche, Helene

AU - Gut, Ivo

AU - Heath, Simon

AU - Lathrop, Mark

AU - Brennan, Paul

AU - Vineis, Paolo

AU - Clavel-Chapelon, Francoise

AU - Palli, Domenico

AU - Tumino, Rosario

AU - Krogh, Vittorio

AU - Panico, Salvatore

AU - González, Carlos A.

AU - Ramón Quirós, José

AU - Martínez, Carmen

AU - Navarro, Carmen

AU - Ardanaz, Eva

AU - Larrãaga, Nerea

AU - Kham, Kay Tee

AU - Key, Timothy

AU - Bueno-De-Mesquita, H. Bas

AU - Peeters, Petra H M

AU - Trichopoulou, Antonia

AU - Linseisen, Jakob

AU - Boeing, Heiner

AU - Hallmans, Göran

AU - Overvad, Kim

AU - Tjønneland, Anne

AU - Kumle, Merethe

AU - Riboli, Elio

PY - 2008/12

Y1 - 2008/12

N2 - We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P = 2 × 10-7 and P = 4 × 10-6) and replicated by the independent study series (P = 7 × 10-5 and P = 0.016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology.

AB - We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P = 2 × 10-7 and P = 4 × 10-6) and replicated by the independent study series (P = 7 × 10-5 and P = 0.016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology.

UR - http://www.scopus.com/inward/record.url?scp=56749182096&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=56749182096&partnerID=8YFLogxK

U2 - 10.1038/ng.254

DO - 10.1038/ng.254

M3 - Article

C2 - 18978790

AN - SCOPUS:56749182096

VL - 40

SP - 1404

EP - 1406

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 12

ER -