Lung cancer risk and occupational exposure to meat and live animals

Raika Durusoy, Paolo Boffetta, Andrea 'T Mannetje, David Zaridze, Neonila Szeszenia-Dabrowska, Peter Rudnai, Jolanta Lissowska, Eleonóra Fabiánová, Adrian Cassidy, Dana Mates, Vladimir Bencko, Frantisek Salajka, Vladimir Janout, Joelle Fevotte, Tony Fletcher, Paul Brennan

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

An increased risk of lung cancer has been reported for butchers and meat workers in several cohort studies, although confounding from tobacco smoking could not be ruled out in any of these studies. These exposures, as well as a potential risk associated with contact with live animals, are addressed here in a large case-control study with full adjustment for smoking. More than 5,900 subjects were included in a case-control study conducted in 7 European countries. For each job they employed local experts who assessed the exposure to a number of occupational agents, including (i) meat aerosols and (ii) live animals, on the basis of detailed occupational questionnaires. Information on tobacco consumption and other risk factors was also collected. A small increased risk of lung cancer was observed with exposure to meat aerosols, after adjusting for smoking, (odds ratio (OR) = 1.27, 95% confidence interval (CI): 0.92, 1.75), which was most apparent for the upper tertile of cumulative exposure (OR = 1.73, 95% CI: 1.03, 2.92). A similar overall effect was observed for exposure to live animals, with an increased risk observed for a high frequency of exposure, (OR = 1.69, 95% CI: 1.21, 2.36) and a high intensity of exposure, (OR = 1.85, 95% CI: 1.16, 2.94), with significant trends for increasing frequency (p = 0.012), intensity (p = 0.015) and cumulative exposure (p = 0.024). In conclusion, this study provides evidence for an association between exposure to meat aerosols and lung cancer apparent in the highest tertile of exposure. The authors identified a more consistent association with exposure to live animals.

Original languageEnglish
Pages (from-to)2543-2547
Number of pages5
JournalInternational Journal of Cancer
Volume118
Issue number10
DOIs
Publication statusPublished - May 15 2006

Keywords

  • Animal viruses
  • Butchers
  • Lung neoplasms
  • Occupation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Lung cancer risk and occupational exposure to meat and live animals'. Together they form a unique fingerprint.

  • Cite this

    Durusoy, R., Boffetta, P., 'T Mannetje, A., Zaridze, D., Szeszenia-Dabrowska, N., Rudnai, P., Lissowska, J., Fabiánová, E., Cassidy, A., Mates, D., Bencko, V., Salajka, F., Janout, V., Fevotte, J., Fletcher, T., & Brennan, P. (2006). Lung cancer risk and occupational exposure to meat and live animals. International Journal of Cancer, 118(10), 2543-2547. https://doi.org/10.1002/ijc.21690