Lung cancer risk among bricklayers in a pooled analysis of case-control studies

Dario Consonni, Sara De Matteis, Angela C. Pesatori, Pier Alberto Bertazzi, Ann C. Olsson, Hans Kromhout, Susan Peters, Roel C H Vermeulen, Beate Pesch, Thomas Brüning, Benjamin Kendzia, Thomas Behrens, Isabelle Stücker, Florence Guida, Heinz Erich Wichmann, Irene Brüske, Maria Teresa Landi, Neil E. Caporaso, Per Gustavsson, Nils PlatoLap Ah Tse, Ignatius Tak Sun Yu, Karl Heinz Jöckel, Wolfgang Ahrens, Hermann Pohlabeln, Franco Merletti, Lorenzo Richiardi, Lorenzo Simonato, Francesco Forastiere, Jack Siemiatycki, Marie Élise Parent, Adonina Tardón, Paolo Boffetta, David Zaridze, Ying Chen, John K. Field, Andrea'T Mannetje, Neil Pearce, John McLaughlin, Paul Demers, Jolanta Lissowska, Neonila Szeszenia-Dabrowska, Vladimir Bencko, Lenka Foretova, Vladimir Janout, P. Rudnai, Eleonóra Fabiánová, Rodica Stanescu Dumitru, H. B. Bueno-De-Mesquita, Joachim Schüz, Kurt Straif

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Bricklayers may be exposed to several lung carcinogens, including crystalline silica and asbestos. Previous studies that analyzed lung cancer risk among these workers had several study design limitations. We examined lung cancer risk among bricklayers within SYNERGY, a large international pooled analysis of case-control studies on lung cancer and the joint effects of occupational carcinogens. For men ever employed as bricklayers we estimated odds ratios (OR) and 95% confidence intervals (CI) adjusted for study center, age, lifetime smoking history and employment in occupations with exposures to known or suspected lung carcinogens. Among 15,608 cases and 18,531 controls, there were 695 cases and 469 controls who had ever worked as bricklayers (OR: 1.47; 95% CI: 1.28-1.68). In studies using population controls the OR was 1.55 (95% CI: 1.32- 1.81, 540/349 cases/controls), while it was 1.24 (95% CI: 0.93-1.64, 155/120 cases/controls) in hospital-based studies. There was a clear positive trend with length of employment (p <0.001). The relative risk was higher for squamous (OR: 1.68, 95% CI: 1.42-1.98, 309 cases) and small cell carcinomas (OR: 1.78, 95% CI: 1.44-2.20, 140 cases), than for adenocarcinoma (OR: 1.17, 95% CI: 0.95-1.43, 150 cases) (p-homogeneity: 0.0007). ORs were still elevated after additional adjustment for education and in analyses using blue collar workers as referents. This study provided robust evidence of increased lung cancer risk in bricklayers. Although non-causal explanations cannot be completely ruled out, the association is plausible in view of the potential for exposure to several carcinogens, notably crystalline silica and to a lesser extent asbestos.

Original languageEnglish
Pages (from-to)360-371
Number of pages12
JournalInternational Journal of Cancer
Volume136
DOIs
Publication statusPublished - 2015

Fingerprint

Case-Control Studies
Lung Neoplasms
Confidence Intervals
Odds Ratio
Carcinogens
Asbestos
Silicon Dioxide
Lung
Small Cell Carcinoma
Population Control
Occupations
Adenocarcinoma
Smoking
History
Education

Keywords

  • Bricklayers
  • Case-control studies
  • Epidemiology
  • Lung neoplasms
  • Occupational health

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Consonni, D., De Matteis, S., Pesatori, A. C., Bertazzi, P. A., Olsson, A. C., Kromhout, H., ... Straif, K. (2015). Lung cancer risk among bricklayers in a pooled analysis of case-control studies. International Journal of Cancer, 136, 360-371. https://doi.org/10.1002/ijc.28986

Lung cancer risk among bricklayers in a pooled analysis of case-control studies. / Consonni, Dario; De Matteis, Sara; Pesatori, Angela C.; Bertazzi, Pier Alberto; Olsson, Ann C.; Kromhout, Hans; Peters, Susan; Vermeulen, Roel C H; Pesch, Beate; Brüning, Thomas; Kendzia, Benjamin; Behrens, Thomas; Stücker, Isabelle; Guida, Florence; Wichmann, Heinz Erich; Brüske, Irene; Landi, Maria Teresa; Caporaso, Neil E.; Gustavsson, Per; Plato, Nils; Tse, Lap Ah; Yu, Ignatius Tak Sun; Jöckel, Karl Heinz; Ahrens, Wolfgang; Pohlabeln, Hermann; Merletti, Franco; Richiardi, Lorenzo; Simonato, Lorenzo; Forastiere, Francesco; Siemiatycki, Jack; Parent, Marie Élise; Tardón, Adonina; Boffetta, Paolo; Zaridze, David; Chen, Ying; Field, John K.; Mannetje, Andrea'T; Pearce, Neil; McLaughlin, John; Demers, Paul; Lissowska, Jolanta; Szeszenia-Dabrowska, Neonila; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; Rudnai, P.; Fabiánová, Eleonóra; Dumitru, Rodica Stanescu; Bueno-De-Mesquita, H. B.; Schüz, Joachim; Straif, Kurt.

In: International Journal of Cancer, Vol. 136, 2015, p. 360-371.

Research output: Contribution to journalArticle

Consonni, D, De Matteis, S, Pesatori, AC, Bertazzi, PA, Olsson, AC, Kromhout, H, Peters, S, Vermeulen, RCH, Pesch, B, Brüning, T, Kendzia, B, Behrens, T, Stücker, I, Guida, F, Wichmann, HE, Brüske, I, Landi, MT, Caporaso, NE, Gustavsson, P, Plato, N, Tse, LA, Yu, ITS, Jöckel, KH, Ahrens, W, Pohlabeln, H, Merletti, F, Richiardi, L, Simonato, L, Forastiere, F, Siemiatycki, J, Parent, MÉ, Tardón, A, Boffetta, P, Zaridze, D, Chen, Y, Field, JK, Mannetje, AT, Pearce, N, McLaughlin, J, Demers, P, Lissowska, J, Szeszenia-Dabrowska, N, Bencko, V, Foretova, L, Janout, V, Rudnai, P, Fabiánová, E, Dumitru, RS, Bueno-De-Mesquita, HB, Schüz, J & Straif, K 2015, 'Lung cancer risk among bricklayers in a pooled analysis of case-control studies', International Journal of Cancer, vol. 136, pp. 360-371. https://doi.org/10.1002/ijc.28986
Consonni D, De Matteis S, Pesatori AC, Bertazzi PA, Olsson AC, Kromhout H et al. Lung cancer risk among bricklayers in a pooled analysis of case-control studies. International Journal of Cancer. 2015;136:360-371. https://doi.org/10.1002/ijc.28986
Consonni, Dario ; De Matteis, Sara ; Pesatori, Angela C. ; Bertazzi, Pier Alberto ; Olsson, Ann C. ; Kromhout, Hans ; Peters, Susan ; Vermeulen, Roel C H ; Pesch, Beate ; Brüning, Thomas ; Kendzia, Benjamin ; Behrens, Thomas ; Stücker, Isabelle ; Guida, Florence ; Wichmann, Heinz Erich ; Brüske, Irene ; Landi, Maria Teresa ; Caporaso, Neil E. ; Gustavsson, Per ; Plato, Nils ; Tse, Lap Ah ; Yu, Ignatius Tak Sun ; Jöckel, Karl Heinz ; Ahrens, Wolfgang ; Pohlabeln, Hermann ; Merletti, Franco ; Richiardi, Lorenzo ; Simonato, Lorenzo ; Forastiere, Francesco ; Siemiatycki, Jack ; Parent, Marie Élise ; Tardón, Adonina ; Boffetta, Paolo ; Zaridze, David ; Chen, Ying ; Field, John K. ; Mannetje, Andrea'T ; Pearce, Neil ; McLaughlin, John ; Demers, Paul ; Lissowska, Jolanta ; Szeszenia-Dabrowska, Neonila ; Bencko, Vladimir ; Foretova, Lenka ; Janout, Vladimir ; Rudnai, P. ; Fabiánová, Eleonóra ; Dumitru, Rodica Stanescu ; Bueno-De-Mesquita, H. B. ; Schüz, Joachim ; Straif, Kurt. / Lung cancer risk among bricklayers in a pooled analysis of case-control studies. In: International Journal of Cancer. 2015 ; Vol. 136. pp. 360-371.
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abstract = "Bricklayers may be exposed to several lung carcinogens, including crystalline silica and asbestos. Previous studies that analyzed lung cancer risk among these workers had several study design limitations. We examined lung cancer risk among bricklayers within SYNERGY, a large international pooled analysis of case-control studies on lung cancer and the joint effects of occupational carcinogens. For men ever employed as bricklayers we estimated odds ratios (OR) and 95{\%} confidence intervals (CI) adjusted for study center, age, lifetime smoking history and employment in occupations with exposures to known or suspected lung carcinogens. Among 15,608 cases and 18,531 controls, there were 695 cases and 469 controls who had ever worked as bricklayers (OR: 1.47; 95{\%} CI: 1.28-1.68). In studies using population controls the OR was 1.55 (95{\%} CI: 1.32- 1.81, 540/349 cases/controls), while it was 1.24 (95{\%} CI: 0.93-1.64, 155/120 cases/controls) in hospital-based studies. There was a clear positive trend with length of employment (p <0.001). The relative risk was higher for squamous (OR: 1.68, 95{\%} CI: 1.42-1.98, 309 cases) and small cell carcinomas (OR: 1.78, 95{\%} CI: 1.44-2.20, 140 cases), than for adenocarcinoma (OR: 1.17, 95{\%} CI: 0.95-1.43, 150 cases) (p-homogeneity: 0.0007). ORs were still elevated after additional adjustment for education and in analyses using blue collar workers as referents. This study provided robust evidence of increased lung cancer risk in bricklayers. Although non-causal explanations cannot be completely ruled out, the association is plausible in view of the potential for exposure to several carcinogens, notably crystalline silica and to a lesser extent asbestos.",
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AU - De Matteis, Sara

AU - Pesatori, Angela C.

AU - Bertazzi, Pier Alberto

AU - Olsson, Ann C.

AU - Kromhout, Hans

AU - Peters, Susan

AU - Vermeulen, Roel C H

AU - Pesch, Beate

AU - Brüning, Thomas

AU - Kendzia, Benjamin

AU - Behrens, Thomas

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AU - Wichmann, Heinz Erich

AU - Brüske, Irene

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AU - Plato, Nils

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AU - Yu, Ignatius Tak Sun

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AU - Richiardi, Lorenzo

AU - Simonato, Lorenzo

AU - Forastiere, Francesco

AU - Siemiatycki, Jack

AU - Parent, Marie Élise

AU - Tardón, Adonina

AU - Boffetta, Paolo

AU - Zaridze, David

AU - Chen, Ying

AU - Field, John K.

AU - Mannetje, Andrea'T

AU - Pearce, Neil

AU - McLaughlin, John

AU - Demers, Paul

AU - Lissowska, Jolanta

AU - Szeszenia-Dabrowska, Neonila

AU - Bencko, Vladimir

AU - Foretova, Lenka

AU - Janout, Vladimir

AU - Rudnai, P.

AU - Fabiánová, Eleonóra

AU - Dumitru, Rodica Stanescu

AU - Bueno-De-Mesquita, H. B.

AU - Schüz, Joachim

AU - Straif, Kurt

PY - 2015

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KW - Case-control studies

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