Lung cancer among coal miners, ore miners and quarrymen: Smoking-adjusted risk estimates from the synergy pooled analysis of case—control studies

Dirk Taeger, Beate Pesch, Benjamin Kendzia, Thomas Behrens, Karl Heinz Jöckel, Dirk Dahmann, Jack Siemiatycki, Hans Kromhout, Roel Vermeulen, Susan Peters, Ann Olsson, Irene Brüske, Heinz Erich Wichmann, Isabelle Stücker, Florence Guida, Adonina Tardón, Franco Merletti, Dario Mirabelli, Lorenzo Richiardi, Hermann PohlabelnWolfgang Ahrens, Maria Teresa Landi, Neil Caporaso, Angela Cecilia Pesatori, Anush Mukeriya, Neonila Szeszenia-Dabrowska, Jolanta Lissowska, Per Gustavsson, John Field, Michael W. Marcus, Eleonora Fabianova, Andrea‘ T. Mannetje, Neil Pearce, Peter Rudnai, Vladimir Bencko, Vladimir Janout, Rodica Stanescu Dumitru, Lenka Foretova, Francesco Forastiere, John McLaughlin, Paul Demers, Bas Bueno-De-Mesquita, Joachim Schüz, Kurt Straif, Thomas Brüning

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objectives Working in mines and quarries has been associated with an elevated lung cancer risk but with inconsistent results for coal miners. This study aimed to estimate the smoking-adjusted lung cancer risk among coal miners and compare the risk pattern with lung cancer risks among ore miners and quarrymen. Methods We estimated lung cancer risks of coal and ore miners and quarrymen among 14 251 lung cancer cases and 17 267 controls from the SYNERGY pooled case–control study, controlling for smoking and employment in other at-risk occupations. Results Ever working as miner or quarryman (690 cases, 436 controls) was associated with an elevated odds ratio (OR) of 1.55 [95% confidence interval (95% CI) 1.34–1.79] for lung cancer. Ore miners (53 cases, 24 controls) had a higher OR (2.34, 95% CI 1.36-4.03) than quarrymen (67 cases, 39 controls; OR 1.92, 95% CI 1.21–3.05) and coal miners (442 cases, 297 controls; OR 1.40, 95% CI 1.18–1.67), but CI overlapped. We did not observe trends by duration of exposure or time since last exposure. Conclusions This pooled analysis of population-based studies demonstrated an excess lung cancer risk among miners and quarrymen that remained increased after adjustment for detailed smoking history and working in other at-risk occupations. The increase in risk among coal miners were less pronounced than for ore miners or quarrymen.

Original languageEnglish
Pages (from-to)467-477
Number of pages11
JournalScandinavian Journal of Work, Environment and Health
Volume41
Issue number5
DOIs
Publication statusPublished - Sep 5 2015

Keywords

  • Coal mining
  • Histological subtype
  • Mining
  • Ore mining
  • Population-based study

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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    Taeger, D., Pesch, B., Kendzia, B., Behrens, T., Jöckel, K. H., Dahmann, D., Siemiatycki, J., Kromhout, H., Vermeulen, R., Peters, S., Olsson, A., Brüske, I., Wichmann, H. E., Stücker, I., Guida, F., Tardón, A., Merletti, F., Mirabelli, D., Richiardi, L., ... Brüning, T. (2015). Lung cancer among coal miners, ore miners and quarrymen: Smoking-adjusted risk estimates from the synergy pooled analysis of case—control studies. Scandinavian Journal of Work, Environment and Health, 41(5), 467-477. https://doi.org/10.5271/sjweh.3513