Lumbar cerebrospinal fluid concentrations of somatostatin and neuropeptide y in multiple sclerosis

László Vécsei, Béla Csala, Erik Widerlöv, Rolf Ekman, József Czopf, György Pàlffy

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The cerebrospinal fluid (CSF) concentrations of somatostatin and neuropeptide Y were investigated by use of radioimmunoassay in patients suffering from chronic progressive multiple sclerosis. The somatostatin level was significantly decreased in the CSF of patients with multiple sclerosis compared to the control group. The magnitude of this change was more pronounced in patients with severe clinical symptoms of the illness. The CSF neuropeptide Y concentration did not differ from the control values. These findings suggest a selective involvement of somatostatin neurotransmission in multiple sclerosis.

Original languageEnglish
Pages (from-to)411-413
Number of pages3
JournalBrain Research Bulletin
Volume25
Issue number3
DOIs
Publication statusPublished - Sep 1990

Keywords

  • CSF
  • Multiple sclerosis
  • Neuropeptide
  • Somatostatin
  • Y

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Lumbar cerebrospinal fluid concentrations of somatostatin and neuropeptide y in multiple sclerosis'. Together they form a unique fingerprint.

  • Cite this