Luffolide, a novel anti-inflammatory terpene from the sponge Luffariella sp.

M. R. Kernan, D. J. Faulkner, L. Parkanyi, J. Clardy, M. S. de Carvalho, R. S. Jacobs

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40 Citations (Scopus)

Abstract

Luffolide (4) is a minor metabolite of the sponge Luffariella sp. from Palau. The structure of luffolide was determined by single crystal X-ray analysis. Luffolide is relatively unstable and undergoes a complex cyclization reaction to give the hexacyclic products 5 and 6. Luffolide (4) has some of the anti-inflammatory properties of manoalide (1): this may help to define the chemical reaction between manoalide (1) and phospholipase A2.

Original languageEnglish
Pages (from-to)388-390
Number of pages3
JournalExperientia
Volume45
Issue number4
DOIs
Publication statusPublished - Apr 1 1989

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Keywords

  • Luffariella sp
  • Luffolide
  • X-ray structure determination
  • anti-inflammatory
  • phospholipase A

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Kernan, M. R., Faulkner, D. J., Parkanyi, L., Clardy, J., de Carvalho, M. S., & Jacobs, R. S. (1989). Luffolide, a novel anti-inflammatory terpene from the sponge Luffariella sp. Experientia, 45(4), 388-390. https://doi.org/10.1007/BF01957489