Lu-177-Labeled Zirconia Particles for Radiation Synovectomy

Andras Polyak, Lívia Naszályi Nagy, Eszter Drotár, Gabriella Dabasi, Róbert P. Jóba, Zita Pöstényi, Renata Mikolajczak, A. Bóta, L. Balogh

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5 Citations (Scopus)

Abstract

The present article describes the preparation of β-emitter lutetium-177-labeled zirconia colloid and its preliminary physicochemical and biological evaluation of suitability for local radionuclide therapy. The new 177Lu-labeled therapeutic radiopharmaceutical candidate was based on the synthesis mode of a previously described zirconia nanoparticle system. The size and shape of the developed radiopharmaceutical compound were observed through a scanning electron microscope and dynamic light scattering methods. The radiocolloid had a 1.7 μm mean diameter and showed high in vitro radiochemical and colloid size stability at room temperature and during the blood sera stability test. After the in vitro characterizations, the product was investigated in the course of the treatment of a spontaneously diseased dog veterinary patient's hock joint completed with single-photon emission computed tomography (SPECT) imaging follow-up measurements and a dual-isotope SPECT imaging tests with conventional 99mTc-methanediphosphonic acid bone scintigraphy. In the treated dog, no clinical side-effects or signs of histopathological changes of the joints were recorded during the treatment. SPECT follow-up studies clearly and conspicuously showed the localization of the 177Lu-labeled colloid in the hock joint as well as detectable but negligible leakages of the radiocolloid in the nearest lymph node. On the basis of biological follow-up tests, the orthopedic team assumed that the 177Lu-labeled zirconia colloid-based local radionuclide therapy resulted in a significant and long-term improvement in clinical signs of the patient without any remarkable side-effects.

Original languageEnglish
Pages (from-to)433-438
Number of pages6
JournalCancer Biotherapy and Radiopharmaceuticals
Volume30
Issue number10
DOIs
Publication statusPublished - Dec 1 2015

Keywords

  • 177Lu
  • Local radiotherapy
  • Radionuclide therapy
  • Radiosynovectomy
  • Rheumatoid arthritis
  • Zirconia

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology

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  • Cite this

    Polyak, A., Nagy, L. N., Drotár, E., Dabasi, G., Jóba, R. P., Pöstényi, Z., Mikolajczak, R., Bóta, A., & Balogh, L. (2015). Lu-177-Labeled Zirconia Particles for Radiation Synovectomy. Cancer Biotherapy and Radiopharmaceuticals, 30(10), 433-438. https://doi.org/10.1089/cbr.2015.1881