Lowering the Detection Limit of Solvent Polymeric Ion-Selective Membrane Electrodes. An Experimental Study with Calcium-Selective Micropipette Electrodes

Mikael Södergård, Balázs Csóka, Géza Nagy, Ari Ivaska

Research output: Contribution to journalArticle

6 Citations (Scopus)


Ion-selective microelectrodes (ISMEs) in the range of 2-90 μm were investigated using different composition of inner reference electrolytes (IRE). The electrodes prepared were PVC-free solvent polymeric based calcium-selective (Ca-ISMEs) micropipette ones. Efforts were done to find an optimal composition of the membrane, IRE, and pipette size in order to reduce the apparent super-Nerstian part of the calibration curves for Ca2+-measurements in the submicromolar range. As a result, we could find an optimal composition, which was linear down to about 10-8 M.

Original languageEnglish
Pages (from-to)2909-2923
Number of pages15
JournalAnalytical Letters
Issue number14
Publication statusPublished - Dec 15 2003



  • Calcium-selective electrode
  • Inner reference solution
  • Ion-selective microelectrodes
  • Lower detection limit
  • Polymer membrane electrode

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Spectroscopy
  • Clinical Biochemistry
  • Biochemistry, medical
  • Electrochemistry

Cite this