Lower n-3 long-chain polyunsaturated fatty acid values in patients with phenylketonuria: A systematic review and meta-analysis

Szimonetta Lohner, Katalin Fekete, T. Decsi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The mainstream of phenylketonuria (PKU) management is lifelong restriction of protein intake; however, this dietary restriction may be accompanied by insufficient dietary intake of long-chain polyunsaturated fatty acids (LCPUFA). The objective of this review was to assess whether significant depletion of LCPUFA can be detected in PKU patients on low-protein diet and whether LCPUFA supplementation is an effective way to increase the availability of LCPUFA in PKU patients. The method included structured search strategy on Ovid MEDLINE, Scopus, LILACS, and the Cochrane Library CENTRAL databases, with formal inclusion/exclusion criteria, data extraction procedure, and meta-analysis. We evaluated 9 case-control studies and 6 randomized controlled trials, dated from the inception of the databases to 2012. The meta-analysis of the case-control studies showed significantly lower values of both eicosapentaenoic acid and docosahexaenoic acid (DHA) in all biomarkers investigated and that of arachidonic acid in total plasma lipids in PKU patients as compared with healthy controls. There were sufficient data to demonstrate that dietary DHA supplementation of patients with PKU significantly increases the contribution of DHA to total plasma lipids. In summary, suboptimal LCPUFA status, especially that of n-3 LCPUFA, can be detected in PKU patients. Supplementing DHA to the diet of PKU patients may improve their LCPUFA status; however, further research is needed to determine the optimal supplementation dosage and to establish beneficial functional outcomes.

Original languageEnglish
Pages (from-to)513-520
Number of pages8
JournalNutrition Research
Volume33
Issue number7
DOIs
Publication statusPublished - Jul 2013

Fingerprint

Phenylketonurias
Unsaturated Fatty Acids
Meta-Analysis
Docosahexaenoic Acids
Case-Control Studies
Databases
Lipids
Protein-Restricted Diet
Eicosapentaenoic Acid
Arachidonic Acid
MEDLINE
Libraries
Randomized Controlled Trials
Biomarkers
Diet
Research

Keywords

  • Dietary Supplements
  • Docosahexaenoic acid
  • Fatty acids
  • Phenylketonurias
  • Unsaturated

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Lower n-3 long-chain polyunsaturated fatty acid values in patients with phenylketonuria : A systematic review and meta-analysis. / Lohner, Szimonetta; Fekete, Katalin; Decsi, T.

In: Nutrition Research, Vol. 33, No. 7, 07.2013, p. 513-520.

Research output: Contribution to journalArticle

@article{c076a7c3bb6e4323b3c08e93bfb78976,
title = "Lower n-3 long-chain polyunsaturated fatty acid values in patients with phenylketonuria: A systematic review and meta-analysis",
abstract = "The mainstream of phenylketonuria (PKU) management is lifelong restriction of protein intake; however, this dietary restriction may be accompanied by insufficient dietary intake of long-chain polyunsaturated fatty acids (LCPUFA). The objective of this review was to assess whether significant depletion of LCPUFA can be detected in PKU patients on low-protein diet and whether LCPUFA supplementation is an effective way to increase the availability of LCPUFA in PKU patients. The method included structured search strategy on Ovid MEDLINE, Scopus, LILACS, and the Cochrane Library CENTRAL databases, with formal inclusion/exclusion criteria, data extraction procedure, and meta-analysis. We evaluated 9 case-control studies and 6 randomized controlled trials, dated from the inception of the databases to 2012. The meta-analysis of the case-control studies showed significantly lower values of both eicosapentaenoic acid and docosahexaenoic acid (DHA) in all biomarkers investigated and that of arachidonic acid in total plasma lipids in PKU patients as compared with healthy controls. There were sufficient data to demonstrate that dietary DHA supplementation of patients with PKU significantly increases the contribution of DHA to total plasma lipids. In summary, suboptimal LCPUFA status, especially that of n-3 LCPUFA, can be detected in PKU patients. Supplementing DHA to the diet of PKU patients may improve their LCPUFA status; however, further research is needed to determine the optimal supplementation dosage and to establish beneficial functional outcomes.",
keywords = "Dietary Supplements, Docosahexaenoic acid, Fatty acids, Phenylketonurias, Unsaturated",
author = "Szimonetta Lohner and Katalin Fekete and T. Decsi",
year = "2013",
month = "7",
doi = "10.1016/j.nutres.2013.05.003",
language = "English",
volume = "33",
pages = "513--520",
journal = "Nutrition Research",
issn = "0271-5317",
publisher = "Elsevier Inc.",
number = "7",

}

TY - JOUR

T1 - Lower n-3 long-chain polyunsaturated fatty acid values in patients with phenylketonuria

T2 - A systematic review and meta-analysis

AU - Lohner, Szimonetta

AU - Fekete, Katalin

AU - Decsi, T.

PY - 2013/7

Y1 - 2013/7

N2 - The mainstream of phenylketonuria (PKU) management is lifelong restriction of protein intake; however, this dietary restriction may be accompanied by insufficient dietary intake of long-chain polyunsaturated fatty acids (LCPUFA). The objective of this review was to assess whether significant depletion of LCPUFA can be detected in PKU patients on low-protein diet and whether LCPUFA supplementation is an effective way to increase the availability of LCPUFA in PKU patients. The method included structured search strategy on Ovid MEDLINE, Scopus, LILACS, and the Cochrane Library CENTRAL databases, with formal inclusion/exclusion criteria, data extraction procedure, and meta-analysis. We evaluated 9 case-control studies and 6 randomized controlled trials, dated from the inception of the databases to 2012. The meta-analysis of the case-control studies showed significantly lower values of both eicosapentaenoic acid and docosahexaenoic acid (DHA) in all biomarkers investigated and that of arachidonic acid in total plasma lipids in PKU patients as compared with healthy controls. There were sufficient data to demonstrate that dietary DHA supplementation of patients with PKU significantly increases the contribution of DHA to total plasma lipids. In summary, suboptimal LCPUFA status, especially that of n-3 LCPUFA, can be detected in PKU patients. Supplementing DHA to the diet of PKU patients may improve their LCPUFA status; however, further research is needed to determine the optimal supplementation dosage and to establish beneficial functional outcomes.

AB - The mainstream of phenylketonuria (PKU) management is lifelong restriction of protein intake; however, this dietary restriction may be accompanied by insufficient dietary intake of long-chain polyunsaturated fatty acids (LCPUFA). The objective of this review was to assess whether significant depletion of LCPUFA can be detected in PKU patients on low-protein diet and whether LCPUFA supplementation is an effective way to increase the availability of LCPUFA in PKU patients. The method included structured search strategy on Ovid MEDLINE, Scopus, LILACS, and the Cochrane Library CENTRAL databases, with formal inclusion/exclusion criteria, data extraction procedure, and meta-analysis. We evaluated 9 case-control studies and 6 randomized controlled trials, dated from the inception of the databases to 2012. The meta-analysis of the case-control studies showed significantly lower values of both eicosapentaenoic acid and docosahexaenoic acid (DHA) in all biomarkers investigated and that of arachidonic acid in total plasma lipids in PKU patients as compared with healthy controls. There were sufficient data to demonstrate that dietary DHA supplementation of patients with PKU significantly increases the contribution of DHA to total plasma lipids. In summary, suboptimal LCPUFA status, especially that of n-3 LCPUFA, can be detected in PKU patients. Supplementing DHA to the diet of PKU patients may improve their LCPUFA status; however, further research is needed to determine the optimal supplementation dosage and to establish beneficial functional outcomes.

KW - Dietary Supplements

KW - Docosahexaenoic acid

KW - Fatty acids

KW - Phenylketonurias

KW - Unsaturated

UR - http://www.scopus.com/inward/record.url?scp=84879889129&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879889129&partnerID=8YFLogxK

U2 - 10.1016/j.nutres.2013.05.003

DO - 10.1016/j.nutres.2013.05.003

M3 - Article

C2 - 23827125

AN - SCOPUS:84879889129

VL - 33

SP - 513

EP - 520

JO - Nutrition Research

JF - Nutrition Research

SN - 0271-5317

IS - 7

ER -