Lower ligand denticity leading to improved thermodynamic and kinetic stability of the Gd 3+ complex: The strange case of OBETA

Zsolt Baranyai, Mauro Botta, Marianna Fekete, Giovanni B. Giovenzana, Roberto Negri, Lorenzo Tei, Carlos Platas-Iglesias

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

OBETA, OBETA, you bet: Thermodynamic and kinetic measurements show an apparent paradox. The stability of complexes of lanthanide trivalent ions is higher with the heptadentate ligand OBETA (ethylene glycol-bis(2-aminoethyl ether)-N,N,N',N'-tetraacetic acid) than with its octadentate homologue EGTA (2,2'-oxybis(ethylamine)-N,N,N',N'-tetraacetic acid). The unusual properties of GdACHTUNGTRENUNG(OBETA) (see structure), combined with the presence of two fast exchanging coordinated water molecules, candidates this complex as an MRI contrast agent.

Original languageEnglish
Pages (from-to)7680-7685
Number of pages6
JournalChemistry - A European Journal
Volume18
Issue number25
DOIs
Publication statusPublished - Jun 18 2012

Keywords

  • Contrast agents
  • Kinetics
  • Lanthanides
  • Magnetic resonance imaging
  • Thermodynamics

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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