Lower fetal status of docosahexaenoic acid, arachidonic acid and essential fatty acids is associated with less favorable neonatal neurological condition

D. A Janneke Dijck-Brouwer, Mijna Hadders-Algra, Hylco Bouwstra, T. Decsi, Günther Boehm, Ingrid A. Martini, E. Rudy Boersma, Frits A J Muskiet

Research output: Contribution to journalArticle

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Abstract

Long-chain polyunsaturated fatty acids, notably arachidonic (AA) and docosahexaenoic (DHA) acids are abundant in brain and may be conditionally essential in fetal life. We investigated umbilical artery (UA) and vein (UV) fatty acid compositions and early neonatal neurological condition in 317 term infants. Neurological condition was summarized as a clinical classification and a 'neurological optimality score' (NOS). Neurologically abnormal infants (n=27) had lower UV DHA and essential fatty acid (EFA) status. NOS correlated positively with AA (UV), and EFA (UV) and DHA status (UV and UA) and negatively with 18:2ω6 and ω9 (UV), and 20:3ω9, ω7 and C18 trans fatty acids (UV and UA). UV DHA, AA, saturated fatty acids, gestational age and obstetrical optimality score explained 16.2% of the NOS variance. Early postnatal neurological condition seems negatively influenced by lower fetal DHA, AA and EFA status. C18 trans fatty acids and 18:2ω6 may exert negative effects by impairment of LCP status.

Original languageEnglish
Pages (from-to)21-28
Number of pages8
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume72
Issue number1
DOIs
Publication statusPublished - Jan 2005

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Essential Fatty Acids
Docosahexaenoic Acids
Arachidonic Acid
Trans Fatty Acids
Veins
Fatty Acids
Umbilical Arteries
Unsaturated Fatty Acids
Brain
Arachidonic Acids
Umbilical Veins
Chemical analysis
Gestational Age

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Lower fetal status of docosahexaenoic acid, arachidonic acid and essential fatty acids is associated with less favorable neonatal neurological condition. / Dijck-Brouwer, D. A Janneke; Hadders-Algra, Mijna; Bouwstra, Hylco; Decsi, T.; Boehm, Günther; Martini, Ingrid A.; Boersma, E. Rudy; Muskiet, Frits A J.

In: Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 72, No. 1, 01.2005, p. 21-28.

Research output: Contribution to journalArticle

Dijck-Brouwer, D. A Janneke ; Hadders-Algra, Mijna ; Bouwstra, Hylco ; Decsi, T. ; Boehm, Günther ; Martini, Ingrid A. ; Boersma, E. Rudy ; Muskiet, Frits A J. / Lower fetal status of docosahexaenoic acid, arachidonic acid and essential fatty acids is associated with less favorable neonatal neurological condition. In: Prostaglandins Leukotrienes and Essential Fatty Acids. 2005 ; Vol. 72, No. 1. pp. 21-28.
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