Lower economic status and inferior hygienic environment may protect against celiac disease

Anita Kondrashova, Kirsi Mustalahti, Katri Kaukinen, Hanna Viskari, Vera Volodicheva, Anna Maija Haapala, Jorma Ilonen, Mikael Knip, Markku Mäki, Heikki Hyöty, H. Hyöty, M. Knip, H. Viskari, J. Ilonen, A. Reunanen, R. Uibo, L. Salur, J. Ludvigsson, D. Marciulionyte, R. HermannG. Soltész, M. Füchtenbusch, A. Ziegler, A. Kondrashova, A. Romanov

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Background. The populations in adjacent Russian Karelia and Finland are equally exposed to grain products and share partly the same ancestry, but live in completely different socioeconomic environments. Aim. This creates an ideal epidemiological setting to study gene-environmental interactions in pathogenesis of celiac disease. Methods. The prevalence of celiac disease and predisposing human leukocyte antigen (HLA) alleles was compared between Russian Karelia and Finland. Tissue transglutaminase antibodies and HLA-DQ alleles were screened from 1988 schoolchildren from Karelia and 3654 children from Finland. Children with transglutaminase antibodies were invited to small-bowel biopsy. Results. Transglutaminase antibodies were less frequent in Russian Karelia than in Finland (0.6% versus 1.4%, P = 0.005). Immunoglobulin class G (IgG) antigliadin antibodies were also less frequent in Russian Karelia (10.2% versus 28.3%, P

Original languageEnglish
Pages (from-to)223-231
Number of pages9
JournalAnnals of Medicine
Volume40
Issue number3
DOIs
Publication statusPublished - 2008

Fingerprint

Celiac Disease
Finland
Economics
Transglutaminases
Antibodies
HLA Antigens
Alleles
Immunoglobulin Isotypes
Immunoglobulin G
Biopsy
Population
Genes

Keywords

  • Celiac disease
  • Children
  • Finland
  • Gluten
  • HLA
  • Prevalence
  • Russia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kondrashova, A., Mustalahti, K., Kaukinen, K., Viskari, H., Volodicheva, V., Haapala, A. M., ... Romanov, A. (2008). Lower economic status and inferior hygienic environment may protect against celiac disease. Annals of Medicine, 40(3), 223-231. https://doi.org/10.1080/07853890701678689

Lower economic status and inferior hygienic environment may protect against celiac disease. / Kondrashova, Anita; Mustalahti, Kirsi; Kaukinen, Katri; Viskari, Hanna; Volodicheva, Vera; Haapala, Anna Maija; Ilonen, Jorma; Knip, Mikael; Mäki, Markku; Hyöty, Heikki; Hyöty, H.; Knip, M.; Viskari, H.; Ilonen, J.; Reunanen, A.; Uibo, R.; Salur, L.; Ludvigsson, J.; Marciulionyte, D.; Hermann, R.; Soltész, G.; Füchtenbusch, M.; Ziegler, A.; Kondrashova, A.; Romanov, A.

In: Annals of Medicine, Vol. 40, No. 3, 2008, p. 223-231.

Research output: Contribution to journalArticle

Kondrashova, A, Mustalahti, K, Kaukinen, K, Viskari, H, Volodicheva, V, Haapala, AM, Ilonen, J, Knip, M, Mäki, M, Hyöty, H, Hyöty, H, Knip, M, Viskari, H, Ilonen, J, Reunanen, A, Uibo, R, Salur, L, Ludvigsson, J, Marciulionyte, D, Hermann, R, Soltész, G, Füchtenbusch, M, Ziegler, A, Kondrashova, A & Romanov, A 2008, 'Lower economic status and inferior hygienic environment may protect against celiac disease', Annals of Medicine, vol. 40, no. 3, pp. 223-231. https://doi.org/10.1080/07853890701678689
Kondrashova A, Mustalahti K, Kaukinen K, Viskari H, Volodicheva V, Haapala AM et al. Lower economic status and inferior hygienic environment may protect against celiac disease. Annals of Medicine. 2008;40(3):223-231. https://doi.org/10.1080/07853890701678689
Kondrashova, Anita ; Mustalahti, Kirsi ; Kaukinen, Katri ; Viskari, Hanna ; Volodicheva, Vera ; Haapala, Anna Maija ; Ilonen, Jorma ; Knip, Mikael ; Mäki, Markku ; Hyöty, Heikki ; Hyöty, H. ; Knip, M. ; Viskari, H. ; Ilonen, J. ; Reunanen, A. ; Uibo, R. ; Salur, L. ; Ludvigsson, J. ; Marciulionyte, D. ; Hermann, R. ; Soltész, G. ; Füchtenbusch, M. ; Ziegler, A. ; Kondrashova, A. ; Romanov, A. / Lower economic status and inferior hygienic environment may protect against celiac disease. In: Annals of Medicine. 2008 ; Vol. 40, No. 3. pp. 223-231.
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AU - Marciulionyte, D.

AU - Hermann, R.

AU - Soltész, G.

AU - Füchtenbusch, M.

AU - Ziegler, A.

AU - Kondrashova, A.

AU - Romanov, A.

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